• Card 11 / 14: A 45 year-old male came to you for consult due to a 3-week history of cough and progressive weight loss. Work-up revealed tuberculosis. He mentioned that he was also diagnosed with cirrhosis after consulting with his gastroenterologist a week ago and that all tests were normal. In starting anti-TB meds, which will you avoid?
    A) None. I will start the usual 4-drug regimen
    B) I will have to avoid at least 2 of the most hepatotoxic drugs
    C) I will not start a regimen with any hepatotoxic drug as he re mainsat risk for drug-induced liver injury
    D) I will avoid pyrazinamide as this is the most hepatotoxic among the anti-TB drugs

    Answer:
    A) None. I will start the usual 4-drug regimen

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Clinical Issues in TB Management

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