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Card 15 / 43:
Explain what happens if even one amino acid is substituted for another in a polypeptide chain. Provide a specific example.
A change in gene sequence can lead to a different amino acid being added to a polypeptide chain instead of the normal one. This causes a change in protein structure and function. For example, in sickle cell anemia, the hemoglobin β chain has a single amino acid substitution. Because of this change, the disc-shaped red blood cells assume a crescent shape, which can result in serious health problems.
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