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This 42-year-old woman with known angina pectoris experienced black stools and hematemesis of one day’s duration. On physicalexamination, she had greatly diminished femoral, popliteal, and pedal pulses together with angioid streaks in both optic fundi.
A disorder of connective tissue characterized by degeneration and calcification of elastic fibers in the skin, eyes, andcardiovascular system. The cutaneous changes resemble “plucked chicken skin” and typically appear in the neck and flexural areas. Angioid streaks representbreaks in the elastic lamina of Bruch’s membrane beneath the retina. Accelerated atherosclerosis at an early age is common. Gastrointestinal bleeding sometimesheralds the disease and presumably results from altered elastic tissue in the walls of small mucosal arteries.
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