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This 77-year-old woman with longstanding polycythemia vera had a six-month history of increasingly prolonged bouts ofredness, swelling, and burning pain in her extremities. The severity and sites of involvement varied with each episode. At presentation, she was unable toambulate without assistance.

151. erythromelalgia

This rare condition derives its name from the Greek words erythros (redness), melos (extremity), and algos (pain). Swelling and increased skin temperature are its other cardinal features. An alternative term, erythermalgia,emphasizes the warmth and inflammation evident in the affected areas. Although erythromelalgia may appear without underlying disease, it occurs most often witha myeloproliferative disorder. Sometimes it precedes the disorder by months to years.

Symptoms frequently begin with an itching sensation followed by burning pain. Fingers, toes, or the entire limb may be affected, andinvolvement may be unilateral or bilateral, symmetric or asymmetric. The redness and swelling ordinarily resolve within several days, but may, as in the patientshown, last for several weeks. If left untreated, this condition may progress to dystrophic changes, painful acrocyanosis, or peripheral gangrene. Heat,standing, and exercise frequently bring on or aggravate the symptoms while resting, elevating, or cooling the involved limb gives relief.

When erythromelalgia accompanies a myeloproliferative disorder, histologic examination of affected tissue showsfibromuscular and intimal proliferation of the dermal arterioles with narrowing of their lumens. In more advanced cases, thrombi are evident. These lesions arethought to result from platelet activation and aggregation in vivo, with in situ thrombosis.

Specific treatment of these patients consists of aspirin to impair platelet aggregation combined with myelosuppressive agentsdesigned to reduce the circulating platelet mass. Such measures in the patient shown afforded substantial clinical improvement.

Questions & Answers

what does nano mean?
Anassong Reply
nano basically means 10^(-9). nanometer is a unit to measure length.
do you think it's worthwhile in the long term to study the effects and possibilities of nanotechnology on viral treatment?
Damian Reply
absolutely yes
how to know photocatalytic properties of tio2 nanoparticles...what to do now
Akash Reply
it is a goid question and i want to know the answer as well
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Do somebody tell me a best nano engineering book for beginners?
s. Reply
what is fullerene does it is used to make bukky balls
Devang Reply
are you nano engineer ?
fullerene is a bucky ball aka Carbon 60 molecule. It was name by the architect Fuller. He design the geodesic dome. it resembles a soccer ball.
what is the actual application of fullerenes nowadays?
That is a great question Damian. best way to answer that question is to Google it. there are hundreds of applications for buck minister fullerenes, from medical to aerospace. you can also find plenty of research papers that will give you great detail on the potential applications of fullerenes.
what is the Synthesis, properties,and applications of carbon nano chemistry
Abhijith Reply
Mostly, they use nano carbon for electronics and for materials to be strengthened.
is Bucky paper clear?
so some one know about replacing silicon atom with phosphorous in semiconductors device?
s. Reply
Yeah, it is a pain to say the least. You basically have to heat the substarte up to around 1000 degrees celcius then pass phosphene gas over top of it, which is explosive and toxic by the way, under very low pressure.
Do you know which machine is used to that process?
how to fabricate graphene ink ?
for screen printed electrodes ?
What is lattice structure?
s. Reply
of graphene you mean?
or in general
in general
Graphene has a hexagonal structure
On having this app for quite a bit time, Haven't realised there's a chat room in it.
what is biological synthesis of nanoparticles
Sanket Reply
what's the easiest and fastest way to the synthesize AgNP?
Damian Reply
types of nano material
abeetha Reply
I start with an easy one. carbon nanotubes woven into a long filament like a string
many many of nanotubes
what is the k.e before it land
what is the function of carbon nanotubes?
I'm interested in nanotube
what is nanomaterials​ and their applications of sensors.
Ramkumar Reply
what is nano technology
Sravani Reply
what is system testing?
preparation of nanomaterial
Victor Reply
how did you get the value of 2000N.What calculations are needed to arrive at it
Smarajit Reply
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Source:  OpenStax, Images of memorable cases: 50 years at the bedside. OpenStax CNX. Dec 08, 2008 Download for free at http://cnx.org/content/col10449/1.7
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