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This 40-year-old homosexual man presented with weakness, weight loss, and painless, nonpruritic facial lesions of six weeks’duration. Similar skin changes were present over his legs and lower trunk. On physical examination, the lesions were papulopustular, round or oval, andsharply demarcated. They varied in size from a few millimeters to several centimeters. Many were umbilicated, some ulcerated, and a few crusted. Themucous membranes were normal.

142. malignant syphilis

Also known as syphilis maligna praecox and lues maligna, this is a rare but completely reversible variant of secondary syphilis.Although its incidence had been decreasing since the beginning of the 20th Century, the number of reported cases has increased of late, most of them inpatients with HIV infection. The skin lesions are pleomorphic, appear in various stages of development, and become widespread, affecting the face and scalp mostoften. They begin as papulopustules, rapidly undergo necrosis, and tend to form deep crusts. Mucous membranes are involved in about a third of the cases.Histologic examination shows dense infiltrates of plasma cells and histiocytes along with obliterative vasculitis of medium-sized vessels. Spirochetes may bevisible in the tissue sections, under dark field microscopy, or both. In addition, a reactive serologic test for syphilis, sometimes with very hightiters, is the rule.

The differential diagnosis includes fungal infection, leishmaniasis, verrucous sarcoidosis, bartonellosis, leprosy, yaws,mycosis fungoides, and pyoderma gangrenosum.

The patient shown had positive serologic tests for syphilis, and after three weeks of penicillin therapy, his skin lesions resolvedcompletely.

Questions & Answers

Introduction about quantum dots in nanotechnology
Praveena Reply
what does nano mean?
Anassong Reply
nano basically means 10^(-9). nanometer is a unit to measure length.
do you think it's worthwhile in the long term to study the effects and possibilities of nanotechnology on viral treatment?
Damian Reply
absolutely yes
how to know photocatalytic properties of tio2 nanoparticles...what to do now
Akash Reply
it is a goid question and i want to know the answer as well
characteristics of micro business
for teaching engĺish at school how nano technology help us
Do somebody tell me a best nano engineering book for beginners?
s. Reply
there is no specific books for beginners but there is book called principle of nanotechnology
what is fullerene does it is used to make bukky balls
Devang Reply
are you nano engineer ?
fullerene is a bucky ball aka Carbon 60 molecule. It was name by the architect Fuller. He design the geodesic dome. it resembles a soccer ball.
what is the actual application of fullerenes nowadays?
That is a great question Damian. best way to answer that question is to Google it. there are hundreds of applications for buck minister fullerenes, from medical to aerospace. you can also find plenty of research papers that will give you great detail on the potential applications of fullerenes.
what is the Synthesis, properties,and applications of carbon nano chemistry
Abhijith Reply
Mostly, they use nano carbon for electronics and for materials to be strengthened.
is Bucky paper clear?
carbon nanotubes has various application in fuel cells membrane, current research on cancer drug,and in electronics MEMS and NEMS etc
so some one know about replacing silicon atom with phosphorous in semiconductors device?
s. Reply
Yeah, it is a pain to say the least. You basically have to heat the substarte up to around 1000 degrees celcius then pass phosphene gas over top of it, which is explosive and toxic by the way, under very low pressure.
Do you know which machine is used to that process?
how to fabricate graphene ink ?
for screen printed electrodes ?
What is lattice structure?
s. Reply
of graphene you mean?
or in general
in general
Graphene has a hexagonal structure
On having this app for quite a bit time, Haven't realised there's a chat room in it.
what is biological synthesis of nanoparticles
Sanket Reply
what's the easiest and fastest way to the synthesize AgNP?
Damian Reply
types of nano material
abeetha Reply
I start with an easy one. carbon nanotubes woven into a long filament like a string
many many of nanotubes
what is the k.e before it land
what is the function of carbon nanotubes?
I'm interested in nanotube
what is nanomaterials​ and their applications of sensors.
Ramkumar Reply
what is nano technology
Sravani Reply
what is system testing?
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Source:  OpenStax, Images of memorable cases: 50 years at the bedside. OpenStax CNX. Dec 08, 2008 Download for free at http://cnx.org/content/col10449/1.7
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