<< Chapter < Page Chapter >> Page >

In the situation called 'meiotic drive', a particular allele ends up in gametes more frequently than others for the same locus. That is, the usual expectation that on average 50% of an individual's gametes contain one allele for a given locus and 50% the other allele for that locus, is violated resulting in the one of the two alleles being overrepresented in gametes of heterozygotes. (The gametes of homozygotes are not affected.)

a. Review Figure 1. What aspect of this diagram would be altered? Why? Please explain.

b. Even if all individuals have an equal probability of mating in this population (i.e. mating occurs randomly), would all alleles have an equal probability of ending up in a fertilization event and thus the next generation? Why or why not? Please explain.

a. The relative quantities of gametes in the 'buckets' of heterozygotes would no longer be 50:50. 'Buckets' corresponding to the allele that ends up in gametes more frequently would contain a larger quantity of gametes than 'buckets' representing the alternative allele.

b. No. All alleles would not have an equal likelihood of ending up in fertilization events even when all individuals are all equally likely to mate. This is true because, when a mating event involves a heterozygote, they will be more likely to contribute the over-represented allele than the alternative allele to fertilization. This is true because more than half their gametes contain the over-represented allele.

In 2005, Stefasson et al. reported the fascinating discovery of an allele, H2, in humans whose presence is associated with increased fertility in Icelandic and European populations. Females with at least one copy of the allele have approximately 3.5%, and males 2.9%, more children on average than non-carriers. The exact mechanism by which the allele affects fertility is unknown.

Do all people in Icelandic and European populations have an equal probability of contributing one of the two gametes to each fertilization event that successfully produces an offspring? Please explain your conclusion.

No, all individuals in these populations do not have an equal probability of contributing one of the two gametes to each fertilization event that produces a surviving offspring. This is true because individuals carrying at least one copy of the allele are more likely to successfully conceive, i.e. have more successful fertilization events, than those that do not carry it.

Researchers investigating the H2 allele discussed in problem 3 hypothesized that this allele could be spreading through the population because of 'transmission disequilibrium' a situation analagous to meiotic drive in that offspring are more likely to inherit the H2 allele over the alternative H1 allele from a heterozygotic parent.

To investigate this, researchers genotyped 3,286 offspring of parents, in which one parent was heterozygous for H2 and the other parent homozygous for the alternative H1 allele, and found that 1,614 of these offspring carried the H2 allele (Stefasson et al. , 2005). Do the data suggest that this allele is spreading through the population as a result of transmission disequilibrium? Yes or no? How do you know? Please explain.

No, the data suggest that this allele is not spreading through the population as a result of transmission disequilibrium because 49% of the offspring of heterozygotes [(1,614/3,286)*100] carry the H2 allele. This compares favorably to the expectation that, if transmission rates are not biased, approximately 50% of the offspring of heterozygotes will carry the H2 allele (and approximately 50% the H1 allele). The two 'buckets' of heterozygotes appear to contain equal quantities of H2 and H1 alleles.

Questions & Answers

find the 15th term of the geometric sequince whose first is 18 and last term of 387
Jerwin Reply
I know this work
The given of f(x=x-2. then what is the value of this f(3) 5f(x+1)
virgelyn Reply
hmm well what is the answer
how do they get the third part x = (32)5/4
kinnecy Reply
can someone help me with some logarithmic and exponential equations.
Jeffrey Reply
sure. what is your question?
okay, so you have 6 raised to the power of 2. what is that part of your answer
I don't understand what the A with approx sign and the boxed x mean
it think it's written 20/(X-6)^2 so it's 20 divided by X-6 squared
I'm not sure why it wrote it the other way
I got X =-6
ok. so take the square root of both sides, now you have plus or minus the square root of 20= x-6
oops. ignore that.
so you not have an equal sign anywhere in the original equation?
is it a question of log
I rally confuse this number And equations too I need exactly help
But this is not salma it's Faiza live in lousvile Ky I garbage this so I am going collage with JCTC that the of the collage thank you my friends
Commplementary angles
Idrissa Reply
im all ears I need to learn
right! what he said ⤴⤴⤴
what is a good calculator for all algebra; would a Casio fx 260 work with all algebra equations? please name the cheapest, thanks.
Kevin Reply
a perfect square v²+2v+_
Dearan Reply
kkk nice
Abdirahman Reply
algebra 2 Inequalities:If equation 2 = 0 it is an open set?
Kim Reply
or infinite solutions?
The answer is neither. The function, 2 = 0 cannot exist. Hence, the function is undefined.
Embra Reply
if |A| not equal to 0 and order of A is n prove that adj (adj A = |A|
Nancy Reply
rolling four fair dice and getting an even number an all four dice
ramon Reply
Kristine 2*2*2=8
Bridget Reply
Differences Between Laspeyres and Paasche Indices
Emedobi Reply
No. 7x -4y is simplified from 4x + (3y + 3x) -7y
Mary Reply
how do you translate this in Algebraic Expressions
linda Reply
Need to simplify the expresin. 3/7 (x+y)-1/7 (x-1)=
Crystal Reply
. After 3 months on a diet, Lisa had lost 12% of her original weight. She lost 21 pounds. What was Lisa's original weight?
Chris Reply
what's the easiest and fastest way to the synthesize AgNP?
Damian Reply
types of nano material
abeetha Reply
I start with an easy one. carbon nanotubes woven into a long filament like a string
many many of nanotubes
what is the k.e before it land
what is the function of carbon nanotubes?
I'm interested in nanotube
what is nanomaterials​ and their applications of sensors.
Ramkumar Reply
what is nano technology
Sravani Reply
what is system testing?
preparation of nanomaterial
Victor Reply
Yes, Nanotechnology has a very fast field of applications and their is always something new to do with it...
Himanshu Reply
good afternoon madam
what is system testing
what is the application of nanotechnology?
In this morden time nanotechnology used in many field . 1-Electronics-manufacturad IC ,RAM,MRAM,solar panel etc 2-Helth and Medical-Nanomedicine,Drug Dilivery for cancer treatment etc 3- Atomobile -MEMS, Coating on car etc. and may other field for details you can check at Google
anybody can imagine what will be happen after 100 years from now in nano tech world
after 100 year this will be not nanotechnology maybe this technology name will be change . maybe aftet 100 year . we work on electron lable practically about its properties and behaviour by the different instruments
name doesn't matter , whatever it will be change... I'm taking about effect on circumstances of the microscopic world
how hard could it be to apply nanotechnology against viral infections such HIV or Ebola?
silver nanoparticles could handle the job?
not now but maybe in future only AgNP maybe any other nanomaterials
I'm interested in Nanotube
this technology will not going on for the long time , so I'm thinking about femtotechnology 10^-15
can nanotechnology change the direction of the face of the world
Prasenjit Reply
At high concentrations (>0.01 M), the relation between absorptivity coefficient and absorbance is no longer linear. This is due to the electrostatic interactions between the quantum dots in close proximity. If the concentration of the solution is high, another effect that is seen is the scattering of light from the large number of quantum dots. This assumption only works at low concentrations of the analyte. Presence of stray light.
Ali Reply
the Beer law works very well for dilute solutions but fails for very high concentrations. why?
bamidele Reply
how did you get the value of 2000N.What calculations are needed to arrive at it
Smarajit Reply
Privacy Information Security Software Version 1.1a
Got questions? Join the online conversation and get instant answers!
QuizOver.com Reply

Get the best Algebra and trigonometry course in your pocket!

Source:  OpenStax, Understanding the hardy-weinberg equation. OpenStax CNX. Oct 22, 2007 Download for free at http://cnx.org/content/col10472/1.1
Google Play and the Google Play logo are trademarks of Google Inc.

Notification Switch

Would you like to follow the 'Understanding the hardy-weinberg equation' conversation and receive update notifications?