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Exercise 1 Enter the letter of any compound that does not meet the structural requirements for the aldol condensation:

Answer: C, F etc……. (Convince yourself)

Exercise 2 Write the letter of any β size 12{β} {} -hydroxyaldehyde or β size 12{β} {} - hydroxyketone?

Answer: B, D etc…….. (Convince yourself)

Exercise 3 Each of the following compounds was prepared by an aldol condensation followed by dehydration. In each case, select the structure of the starting material from the list of choices in the box below.

Answer: (a) FF (b) BB (c) __? __ (Convince yourself)

Exercise 4 Each of the following compounds was prepared by a crossed aldol condensation followed by dehydration. In each case, select the structures of the starting materials from the list of choices in the box above. Enter the letter of the compound that serves as the nucleophilic component followed by that of the electrophilic component. For example, the nucleophilic component used to prepare the first compound is A, while the electrophilic component is F.

Answers: (a) AF (b)

Pre-lab 2: aldol condensation (total 10 points)

Click here for the Pre-Lab

Name(Print then sign): ___________________________________________________

Lab Day: ___________________Section: ________TA__________________________

This assignment must be completed individually and turned in to your TA at the beginning of lab. You will not be allowed to begin the lab until you have completed this assignment.

1) Is this reaction acid or base catalyzed? Why do you need to use 1.0 M HCl at the end of the experiment? (2 points)

2) What is the role of p-nitro group in 4-nitrobenzaldehyde during the ALDOL reaction? What do you think would happen to the yield of the product if p-methoxy group was present instead of p-nitro group? (2 points)

3) Benzaldehyde (PhCHO) cannot undergo“ALDOL”reaction by itself in presence of strong base (KOH)-Why? (1 point)

4) Write the major product of the following reactions, if there is no product specifies it. (1+2+2 = 5 points)


You will be assessed on:

  • Completion of Pre lab questions.
  • Write-up in your Lab Notebook (see Appendix:1 Lab Notebook Guidelines )
  • Completion of Report questions.
  • TA evaluation of lab procedure.

Materials required

Equipment Chemicals

  • Water Bath 4-nitrobenzaldehyde
  • Stir bar Acetophenone
  • Round bottom flask (10mL) Sodium hydroxide
  • Funnel HCl (1.0 M)
  • Beaker Ethanol
  • Glass rod (for recrystalization) Filter paper


Wear gloves all the time, especially when working with NaOH and HCl. Keep safety glasses at all the times.

Experimental procedure

You will be assigned either procedure A (traditional experiment procedures) or procedure B (green chemistry experiment procedures). Comparison of two methods: Give percent yield and melting point temperatures to the TA so that they can be written on the board and you can then collect everyones’data.

A. traditional experiment procedure

Pre-heat your water bath to 60-70°C.

  • Place a stir bar and 0.4 g of 4-nitrobenzaldehyde, 0.3 g of acetophenone and 0.10 g of sodium hydroxide in a 10 mL round bottom flask. NOTE: Acetophenone is a liquid with a density of 1.03 g/mL. Add 3.5 mL of 95% ethanol and heat the reaction mixture to 60-70°C while stirring for 20 minutes. Do not overheat your product otherwise you will polymerize your sample.

Questions & Answers

find the 15th term of the geometric sequince whose first is 18 and last term of 387
Jerwin Reply
The given of f(x=x-2. then what is the value of this f(3) 5f(x+1)
virgelyn Reply
hmm well what is the answer
how do they get the third part x = (32)5/4
kinnecy Reply
can someone help me with some logarithmic and exponential equations.
Jeffrey Reply
sure. what is your question?
okay, so you have 6 raised to the power of 2. what is that part of your answer
I don't understand what the A with approx sign and the boxed x mean
it think it's written 20/(X-6)^2 so it's 20 divided by X-6 squared
I'm not sure why it wrote it the other way
I got X =-6
ok. so take the square root of both sides, now you have plus or minus the square root of 20= x-6
oops. ignore that.
so you not have an equal sign anywhere in the original equation?
is it a question of log
Commplementary angles
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what is a good calculator for all algebra; would a Casio fx 260 work with all algebra equations? please name the cheapest, thanks.
Kevin Reply
a perfect square v²+2v+_
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Abdirahman Reply
algebra 2 Inequalities:If equation 2 = 0 it is an open set?
Kim Reply
or infinite solutions?
The answer is neither. The function, 2 = 0 cannot exist. Hence, the function is undefined.
Embra Reply
if |A| not equal to 0 and order of A is n prove that adj (adj A = |A|
Nancy Reply
rolling four fair dice and getting an even number an all four dice
ramon Reply
Kristine 2*2*2=8
Bridget Reply
Differences Between Laspeyres and Paasche Indices
Emedobi Reply
No. 7x -4y is simplified from 4x + (3y + 3x) -7y
Mary Reply
how do you translate this in Algebraic Expressions
linda Reply
Need to simplify the expresin. 3/7 (x+y)-1/7 (x-1)=
Crystal Reply
. After 3 months on a diet, Lisa had lost 12% of her original weight. She lost 21 pounds. What was Lisa's original weight?
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what's the easiest and fastest way to the synthesize AgNP?
Damian Reply
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abeetha Reply
I start with an easy one. carbon nanotubes woven into a long filament like a string
many many of nanotubes
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I'm interested in nanotube
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Yes, Nanotechnology has a very fast field of applications and their is always something new to do with it...
Himanshu Reply
good afternoon madam
what is system testing
what is the application of nanotechnology?
In this morden time nanotechnology used in many field . 1-Electronics-manufacturad IC ,RAM,MRAM,solar panel etc 2-Helth and Medical-Nanomedicine,Drug Dilivery for cancer treatment etc 3- Atomobile -MEMS, Coating on car etc. and may other field for details you can check at Google
anybody can imagine what will be happen after 100 years from now in nano tech world
after 100 year this will be not nanotechnology maybe this technology name will be change . maybe aftet 100 year . we work on electron lable practically about its properties and behaviour by the different instruments
name doesn't matter , whatever it will be change... I'm taking about effect on circumstances of the microscopic world
how hard could it be to apply nanotechnology against viral infections such HIV or Ebola?
silver nanoparticles could handle the job?
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I'm interested in Nanotube
this technology will not going on for the long time , so I'm thinking about femtotechnology 10^-15
can nanotechnology change the direction of the face of the world
Prasenjit Reply
At high concentrations (>0.01 M), the relation between absorptivity coefficient and absorbance is no longer linear. This is due to the electrostatic interactions between the quantum dots in close proximity. If the concentration of the solution is high, another effect that is seen is the scattering of light from the large number of quantum dots. This assumption only works at low concentrations of the analyte. Presence of stray light.
Ali Reply
the Beer law works very well for dilute solutions but fails for very high concentrations. why?
bamidele Reply
how did you get the value of 2000N.What calculations are needed to arrive at it
Smarajit Reply
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Source:  OpenStax, Chem217labsfall07. OpenStax CNX. Oct 16, 2007 Download for free at http://cnx.org/content/col10463/1.4
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