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Diagnosing rickettsial infection by cultivation in the laboratory is both difficult and hazardous because of the easy aerosolization of the bacteria, so PCR and ELISA are commonly used. Doxycycline is the first-line drug to treat acute Q fever. In chronic Q fever, doxycycline is often paired with hydroxychloroquine .

Bacterial diseases of the respiratory tract

Numerous pathogens can cause infections of the respiratory tract. Many of these infections produce similar signs and symptoms, but appropriate treatment depends on accurate diagnosis through laboratory testing. The tables in [link] and [link] summarize the most important bacterial respiratory infections, with the latter focusing specifically on forms of bacterial pneumonia.

Table titled: Bacterial Infections of the Respiratory Tract. Columns: Disease, Pathogen, Signs and Symptoms, Transmission, Diagnostic Tests, Antimicrobial Drugs, Vaccine. Acute otitis media (AOM); Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis, others;  Earache, possible effusion; may cause fever, nausea, vomiting, diarrhea; Often a secondary infection; bacteria from respiratory tract become trapped in eustachian tube, cause infection; None; Cephalosporins, fluoroquinolones; None. Diphtheria; Corynebacterium diphtheria; Pseudomembrane on throat, possibly leading to suffocation and death; Inhalation of respiratory droplets or aerosols from infected person ; Identification of bacteria in throat swabs; PCR to detect diphtheria toxin in vitro; Erythromycin, penicillin, antitoxin produced in horses; DtaP, Tdap, DT, Td, DTP. Legionnaires disease; Legionella pneumophila; Cough, fever, muscle aches, headaches, nausea, vomiting, confusion; sometimes fatal; Inhalation of aerosols from contaminated water reservoirs; Isolation, using Warthin-Starry procedure, of bacteria in sputum; Fluoroquinolones, macrolides; None. Pertussis (whooping cough); Bordetella pertussis; Severe coughing with “whoop” sound; chronic cough lasting several months; can be fatal in infants; Inhalation of respiratory droplets from infected person; Direct culture of throat swab, PCR, ELISA Macrolides; DTaP, Tdap. Q fever; Coxiella burnetii; High fever, coughing, pneumonia, malaise; in chronic cases, potentially fatal endocarditis; Inhalation of aerosols of urine, feces, milk, or amniotic fluid of infected cattle, sheep, goats; PCR, ELISA; Doxycycline, hydroxychloroquine; None. Streptococcal pharyngitis, scarlet fever; Streptococcus pyogenes; Fever, sore throat, inflammation of pharynx and tonsils, petechiae, swollen lymph nodes; skin rash (scarlet fever), strawberry tongue; Direct contact, inhalation of respiratory droplets or aerosols from infected person Direct culture of throat swab, rapid enzyme immunoassay; β-lactams; None. Tuberculosis; Mycobacterium tuberculosis; Formation of tubercles in lungs; rupture of tubercles, leading to chronic, bloody cough; healed tubercles (Ghon complexes) visible in radiographs; can be fatal; Inhalation of respiratory droplets or aerosols from infected person Mantoux tuberculin skin test with chest radiograph to identify Ghon complexes; Isoniazid, rifampin, ethambutol, pyrazinamide; BCG.
Table titled: Bacterial Causes of Pneumonia. Columns: Disease, Pathogen, Signs and Symptoms, Transmission, Diagnostic Tests, Antimicrobial Drugs, Vaccine. Chlamydial pneumonia; Chlamydophila pneumoniae, C. psittaci, Chlamydia trachomatis; Bronchitis; mild to severe respiratory distress; Inhalation of respiratory droplets or aerosols from infected person (C. pneumoniae); exposure to infected bird (C. psittaci); exposure in the birth canal (Chlamydia trachomatis); Tissue culture, PCR; Tetracycline, macrolides; None. Haemophilus pneumonia; Haemophilus influenza; Cough, fever or low body temperature, chills, chest pain, headache, fatigue; Inhalation of respiratory droplets or aerosols from infected person or asymptomatic carrier; Culture on chocolate agar, serotyping of blood or cerebrospinal fluid samples; Cephalosporins, fluoroquinolones; Hib. Klebsiella pneumonia; Klebsiella pneumoniae, others; Lung necrosis, “currant jelly” sputum; often fatal; Health care associated; bacteria introduced via contaminated ventilators, intubation, or other medical equipment; Multidrug resistant; antibiotic susceptibility testing necessary; None. Mycoplasma pneumonia (walking pneumonia); Mycoplasma pneumoniae; Low fever, persistent cough; Inhalation of respiratory droplets or aerosols from infected person Culture with penicillin, thallium acetate; Macrolides; None. Pneumococcal pneumonia; Streptococcus pneumoniae; Productive cough, bloody sputum, fever, chills, chest pain, respiratory distress; Direct contact with respiratory secretions; Gram stain, blood agar culture with optichin and sodium deoxycholate, quellung reaction; β-lactams, macrolides or cephalosporin , fluoroquinolones; Pneumococcal conjugate vaccine (PCV13), pneumococcal polysaccharide vaccine (PPSV23). Pseudomonas pneumonia; Pseudomonas aeruginosa; Viscous fluid and chronic inflammation of lungs; often fatal; Health care associated; bacteria introduced via contaminated ventilators; also frequently affects patients with cystic fibrosis; Culture from sputum or other body fluid; Multidrug resistant; antibiotic susceptibility testing necessary; None.

Key concepts and summary

  • A wide variety of bacteria can cause respiratory diseases; most are treatable with antibiotics or preventable with vaccines.
  • Streptococcus pyogenes causes strep throat , an infection of the pharynx that also causes high fever and can lead to scarlet fever , acute rheumatic fever , and acute glomerulonephritis .
  • Acute otitis media is an infection of the middle ear that may be caused by several bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis . The infection can block the eustachian tubes, leading to otitis media with effusion .
  • Diphtheria , caused by Corynebacterium diphtheriae , is now a rare disease because of widespread vaccination. The bacteria produce exotoxins that kill cells in the pharynx, leading to the formation of a pseudomembrane ; and damage other parts of the body.
  • Bacterial pneumonia results from infections that cause inflammation and fluid accumulation in the alveoli. It is most commonly caused by S. pneumoniae or H. influenzae . The former is commonly multidrug resistant.
  • Mycoplasma pneumonia results from infection by Mycoplasma pneumoniae ; it can spread quickly, but the disease is mild and self-limiting.
  • Chlamydial pneumonia can be caused by three pathogens that are obligate intracellular parasites. Chlamydophila pneumoniae is typically transmitted from an infected person, whereas C. psittaci is typically transmitted from an infected bird. Chlamydia trachomatis , may cause pneumonia in infants.
  • Several other bacteria can cause pneumonia in immunocompromised individuals and those with cystic fibrosis.
  • Tuberculosis is caused by Mycobacterium tuberculosis . Infection leads to the production of protective tubercles in the alveoli and calcified Ghon complexes that can harbor the bacteria for a long time. Antibiotic-resistant forms are common and treatment is typically long term.
  • Pertussis is caused by Bordetella pertussis . Mucus accumulation in the lungs leads to prolonged severe coughing episodes (whooping cough) that facilitate transmission. Despite an available vaccine, outbreaks are still common.
  • Legionnaires disease is caused by infection from environmental reservoirs of the Legionella pneumophila bacterium. The bacterium is endocytic within macrophages and infection can lead to pneumonia, particularly among immunocompromised individuals.
  • Q fever is caused by Coxiella burnetii , whose primary hosts are domesticated mammals (zoonotic disease). It causes pneumonia primarily in farm workers and can lead to serious complications, such as endocarditis.

Fill in the blank

Calcified lesions called _______ form in the lungs of patients with TB.

Ghon complexes

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An inflammation of the middle ear is called _______.

otitis media

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The _______ is used to serologically identify Streptococcus pneumoniae isolates.

quellung reaction

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_______ is a zoonotic infection that can be contracted by people who handle birds.

Psittacosis

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The main virulence factor involved in scarlet fever is the _______.

erythrogenic toxin

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Short answer

Name three bacteria that commonly cause pneumonia. Which is the most common cause?

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How does smoking make an individual more susceptible to infections?

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How does the diphtheria pathogen form a pseudomembrane?

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Questions & Answers

differentiate between demand and supply giving examples
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In economics, a perfect market refers to a theoretical construct where all participants have perfect information, goods are homogenous, there are no barriers to entry or exit, and prices are determined solely by supply and demand. It's an idealized model used for analysis,
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When MP₁ becomes negative, TP start to decline. Extuples Suppose that the short-run production function of certain cut-flower firm is given by: Q=4KL-0.6K2 - 0.112 • Where is quantity of cut flower produced, I is labour input and K is fixed capital input (K-5). Determine the average product of lab
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Extuples Suppose that the short-run production function of certain cut-flower firm is given by: Q=4KL-0.6K2 - 0.112 • Where is quantity of cut flower produced, I is labour input and K is fixed capital input (K-5). Determine the average product of labour (APL) and marginal product of labour (MPL)
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Quantity demanded refers to the specific amount of a good or service that consumers are willing and able to purchase at a give price and within a specific time period. Demand, on the other hand, is a broader concept that encompasses the entire relationship between price and quantity demanded
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Economic growth as an increase in the production and consumption of goods and services within an economy.but Economic development as a broader concept that encompasses not only economic growth but also social & human well being.
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In economics, the contract curve refers to the set of points in an Edgeworth box diagram where both parties involved in a trade cannot be made better off without making one of them worse off. It represents the Pareto efficient allocations of goods between two individuals or entities, where neither p
Cornelius
In economics, the contract curve refers to the set of points in an Edgeworth box diagram where both parties involved in a trade cannot be made better off without making one of them worse off. It represents the Pareto efficient allocations of goods between two individuals or entities,
Cornelius
Suppose a consumer consuming two commodities X and Y has The following utility function u=X0.4 Y0.6. If the price of the X and Y are 2 and 3 respectively and income Constraint is birr 50. A,Calculate quantities of x and y which maximize utility. B,Calculate value of Lagrange multiplier. C,Calculate quantities of X and Y consumed with a given price. D,alculate optimum level of output .
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Answer
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the market for lemon has 10 potential consumers, each having an individual demand curve p=101-10Qi, where p is price in dollar's per cup and Qi is the number of cups demanded per week by the i th consumer.Find the market demand curve using algebra. Draw an individual demand curve and the market dema
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suppose the production function is given by ( L, K)=L¼K¾.assuming capital is fixed find APL and MPL. consider the following short run production function:Q=6L²-0.4L³ a) find the value of L that maximizes output b)find the value of L that maximizes marginal product
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What is the difference between perfect competition and monopolistic competition?
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Source:  OpenStax, Microbiology. OpenStax CNX. Nov 01, 2016 Download for free at http://cnx.org/content/col12087/1.4
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