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Internal respiration

Internal respiration is gas exchange that occurs at the level of body tissues ( [link] ). Similar to external respiration, internal respiration also occurs as simple diffusion due to a partial pressure gradient. However, the partial pressure gradients are opposite of those present at the respiratory membrane. The partial pressure of oxygen in tissues is low, about 40 mm Hg, because oxygen is continuously used for cellular respiration. In contrast, the partial pressure of oxygen in the blood is about 100 mm Hg. This creates a pressure gradient that causes oxygen to dissociate from hemoglobin, diffuse out of the blood, cross the interstitial space, and enter the tissue. Hemoglobin that has little oxygen bound to it loses much of its brightness, so that blood returning to the heart is more burgundy in color.

Considering that cellular respiration continuously produces carbon dioxide, the partial pressure of carbon dioxide is lower in the blood than it is in the tissue, causing carbon dioxide to diffuse out of the tissue, cross the interstitial fluid, and enter the blood. It is then carried back to the lungs either bound to hemoglobin, dissolved in plasma, or in a converted form. By the time blood returns to the heart, the partial pressure of oxygen has returned to about 40 mm Hg, and the partial pressure of carbon dioxide has returned to about 45 mm Hg. The blood is then pumped back to the lungs to be oxygenated once again during external respiration.

Internal respiration

This diagram details the pathway of internal respiration. The exchange of oxygen and carbon dioxide between a red blood cell and a tissue cell is shown.
Oxygen diffuses out of the capillary and into cells, whereas carbon dioxide diffuses out of cells and into the capillary.

Everyday connection

Hyperbaric chamber treatment

A type of device used in some areas of medicine that exploits the behavior of gases is hyperbaric chamber treatment. A hyperbaric chamber is a unit that can be sealed and expose a patient to either 100 percent oxygen with increased pressure or a mixture of gases that includes a higher concentration of oxygen than normal atmospheric air, also at a higher partial pressure than the atmosphere. There are two major types of chambers: monoplace and multiplace. Monoplace chambers are typically for one patient, and the staff tending to the patient observes the patient from outside of the chamber ( [link] ). Some facilities have special monoplace hyperbaric chambers that allow multiple patients to be treated at once, usually in a sitting or reclining position, to help ease feelings of isolation or claustrophobia. Multiplace chambers are large enough for multiple patients to be treated at one time, and the staff attending these patients is present inside the chamber. In a multiplace chamber, patients are often treated with air via a mask or hood, and the chamber is pressurized.

Hyperbaric chamber

This photo shows two hyperbaric chambers.
(credit: “komunews”/flickr.com)

Hyperbaric chamber treatment is based on the behavior of gases. As you recall, gases move from a region of higher partial pressure to a region of lower partial pressure. In a hyperbaric chamber, the atmospheric pressure is increased, causing a greater amount of oxygen than normal to diffuse into the bloodstream of the patient. Hyperbaric chamber therapy is used to treat a variety of medical problems, such as wound and graft healing, anaerobic bacterial infections, and carbon monoxide poisoning. Exposure to and poisoning by carbon monoxide is difficult to reverse, because hemoglobin’s affinity for carbon monoxide is much stronger than its affinity for oxygen, causing carbon monoxide to replace oxygen in the blood. Hyperbaric chamber therapy can treat carbon monoxide poisoning, because the increased atmospheric pressure causes more oxygen to diffuse into the bloodstream. At this increased pressure and increased concentration of oxygen, carbon monoxide is displaced from hemoglobin. Another example is the treatment of anaerobic bacterial infections, which are created by bacteria that cannot or prefer not to live in the presence of oxygen. An increase in blood and tissue levels of oxygen helps to kill the anaerobic bacteria that are responsible for the infection, as oxygen is toxic to anaerobic bacteria. For wounds and grafts, the chamber stimulates the healing process by increasing energy production needed for repair. Increasing oxygen transport allows cells to ramp up cellular respiration and thus ATP production, the energy needed to build new structures.

Chapter review

The behavior of gases can be explained by the principles of Dalton’s law and Henry’s law, both of which describe aspects of gas exchange. Dalton’s law states that each specific gas in a mixture of gases exerts force (its partial pressure) independently of the other gases in the mixture. Henry’s law states that the amount of a specific gas that dissolves in a liquid is a function of its partial pressure. The greater the partial pressure of a gas, the more of that gas will dissolve in a liquid, as the gas moves toward equilibrium. Gas molecules move down a pressure gradient; in other words, gas moves from a region of high pressure to a region of low pressure. The partial pressure of oxygen is high in the alveoli and low in the blood of the pulmonary capillaries. As a result, oxygen diffuses across the respiratory membrane from the alveoli into the blood. In contrast, the partial pressure of carbon dioxide is high in the pulmonary capillaries and low in the alveoli. Therefore, carbon dioxide diffuses across the respiratory membrane from the blood into the alveoli. The amount of oxygen and carbon dioxide that diffuses across the respiratory membrane is similar.

Ventilation is the process that moves air into and out of the alveoli, and perfusion affects the flow of blood in the capillaries. Both are important in gas exchange, as ventilation must be sufficient to create a high partial pressure of oxygen in the alveoli. If ventilation is insufficient and the partial pressure of oxygen drops in the alveolar air, the capillary is constricted and blood flow is redirected to alveoli with sufficient ventilation. External respiration refers to gas exchange that occurs in the alveoli, whereas internal respiration refers to gas exchange that occurs in the tissue. Both are driven by partial pressure differences.

Questions & Answers

plzzz explain cardiac cycle
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Gifty Reply
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Amos
What are some of first questions are expected in anatomy and physiology course
Milner Reply
what is pacemaker
mekfira
its a device that is put into the heart to make sure it beats properly
Michelle
SA node produces impulse is called pacemaker
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which of the following is the epithelial tissue that lines the interior of blood vessels?
Firomsa Reply
endothelial tissues
Osaki
Endothelial tissue
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riad Reply
the long bone with two primary center's of ossification for shaft is ________
Aarambam
medulla
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doctor and nurse
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There are only six days during any cycle when a woman can get pregnant - the five days leading up to ovulation and the 24 hours after ovulation. This is because sperm can live for up to 5 days in a woman's body, and the ovum lives for only 12-24 hours.
THE
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when after they have intercourse
AJ
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William Reply
It's the men version of menopause!
Catia
The testosterone levels decrease
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Marvin Reply
If our blood sugar drops below 70 mg/dL, we may have symptoms, such as feeling tired, weak, or shaky, become confused or drowsy or even lose consciousness and possibly die.
Dhanya
symptoms of hypoglycemia include: shakiness, dizziness, headache, confusion, rapid pulse rate, sweating, Hunger, etc.
EMERIBE
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I don't think you can disable chat and yes it is on every app
AJ
what is homeostasis
Nikky Reply
what is respiratory
Nikky
Respiratory is breathing
Atone
respiration is an exchange of gases (O2 & CO2) between the body and outside environment.
joey
homeostasis is internal balance.
Ali
Respiratory is system where the body takes in oxygen n releases carbondioxide
Hassan
respiratory system is a system where exhalation and inhalation takes place
Kom
1)inhalation: active diaphragm & external intercoastal muscles 2)exhalation: passive (allow muscle group to relax)
Shoukat
mantaince of body is called homeostasis
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Sakshi
Face ki he ethmoid bone
Rakesh
ethmoid bone. Irregularly shaped bone anterior to the solenoid. Forms the roof of the nasal cavity, upper nasal septum, and part of the medial orbit walls.
LaKecia
Its unpaired bone of skull that saprate the nasal cavity from the brain it's located at the roof of the nose between the two orbits it's bone is one of the bones that make up the orbit of eye.
SARFARAJ
sphenoid I meant
LaKecia
wrist joint ka dusra name kya he
Rakesh
till me fast my ans
Rakesh
Also included in the ethmoid bone is the crista galli and the cribriform plates. The plates help form the roof of the nasal cavity and the floor of the anterior cranial fossa.
LaKecia
the outer most covering of the brain ( the dura mater) attached to the crista galli and helps secure the brain in the cranial cavity
LaKecia
Sakshi Mishra. I hope that helped!
LaKecia
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Khubaib
synovial joint will have present in wrist
sk
what's the smallest blood vessal in the body?
sk
respiration is the process of inspiration an expiration
Bel
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sk
The protection of internal envirnment from the harm of external envirnmen is called as homeostasis.
Rana
Because stem cells have the unique ability to develop into any cell, stem cell therapy is being considered for treatment of kidney damage. What are your thoughts on stem cell treatment? Give at least three reasons for or against the treatment.
Samira Reply
to know the structure of the human body. to study the region of the human body. to understand the circulation of blood in the human body.
Angelashimakela Reply
what do CNS stand for
Angelashimakela Reply
central nervous system
Dustin
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Larita
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rashid
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Angelashimakela
glands are not a part of CNS! but sensory receptors are a part of peripheral nervous system!
rashid
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Angelashimakela
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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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