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Illustration shows cells, shaped like slices of pie, arranged in a circle. The hub of the circle is empty. Three of these circles of cells cluster together.
Simple cuboidal epithelial cells line tubules in the mammalian kidney, where they are involved in filtering the blood.

Columnar epithelia

Columnar epithelial cells are taller than they are wide: they resemble a stack of columns in an epithelial layer, and are most commonly found in a single-layer arrangement. The nuclei of columnar epithelial cells in the digestive tract appear to be lined up at the base of the cells, as illustrated in [link] . These cells absorb material from the lumen of the digestive tract and prepare it for entry into the body through the circulatory and lymphatic systems.

Illustration shows tall, columnar cells arranged side-by-side. Each cell has a nucleus located near the bottom, and cilia extending from the top. Two oval goblet cells are interspersed among the columnar epithelial cells. The goblet cells, which are shorter than the columnar cells, are in direct contact with the intestinal lumen. Beneath the columnar cells is a layer of horizontal cells.
Simple columnar epithelial cells absorb material from the digestive tract. Goblet cells secret mucous into the digestive tract lumen.

Columnar epithelial cells lining the respiratory tract appear to be stratified. However, each cell is attached to the base membrane of the tissue and, therefore, they are simple tissues. The nuclei are arranged at different levels in the layer of cells, making it appear as though there is more than one layer, as seen in [link] . This is called pseudostratified    , columnar epithelia. This cellular covering has cilia at the apical, or free, surface of the cells. The cilia enhance the movement of mucous and trapped particles out of the respiratory tract, helping to protect the system from invasive microorganisms and harmful material that has been breathed into the body. Goblet cells are interspersed in some tissues (such as the lining of the trachea). The goblet cells contain mucous that traps irritants, which in the case of the trachea keep these irritants from getting into the lungs.

Illustration shows columnar cells arranged side-by-side. The cells are wide at the top, and thin at the bottom. Shorter columnar cells are interspersed between the lower, thin part of the tall columnar cells. Some of these cells extend to the surface of the epithelium, but they are very thin at the top. The nuclei of the tall columnar cells are located near the top, and the nuclei of the shorter columnar cells are located near the bottom, giving the appearance of two layers of cells. Cilia extend from the top of the tall columnar cells. Oval goblet cells are interspersed among the columnar epithelial cells. Beneath the columnar cells is a layer of horizontal cells.
Pseudostratified columnar epithelia line the respiratory tract. They exist in one layer, but the arrangement of nuclei at different levels makes it appear that there is more than one layer. Goblet cells interspersed between the columnar epithelial cells secrete mucous into the respiratory tract.

Transitional epithelia

Transitional or uroepithelial cells appear only in the urinary system, primarily in the bladder and ureter. These cells are arranged in a stratified layer, but they have the capability of appearing to pile up on top of each other in a relaxed, empty bladder, as illustrated in [link] . As the urinary bladder fills, the epithelial layer unfolds and expands to hold the volume of urine introduced into it. As the bladder fills, it expands and the lining becomes thinner. In other words, the tissue transitions from thick to thin.

Art connection

Illustration shows tall, diamond-shaped cells layered one on top of the other.
Transitional epithelia of the urinary bladder undergo changes in thickness depending on how full the bladder is.

Which of the following statements about types of epithelial cells is false?

  1. Simple columnar epithelial cells line the tissue of the lung.
  2. Simple cuboidal epithelial cells are involved in the filtering of blood in the kidney.
  3. Pseudostratisfied columnar epithilia occur in a single layer, but the arrangement of nuclei makes it appear that more than one layer is present.
  4. Transitional epithelia change in thickness depending on how full the bladder is.

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Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
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