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At the transition from the DCT to the collecting duct, about 20 percent of the original water is still present and about 10 percent of the sodium. If no other mechanism for water reabsorption existed, about 20–25 liters of urine would be produced. Now consider what is happening in the adjacent capillaries, the vasa recta. They are recovering both solutes and water at a rate that preserves the countercurrent multiplier system. In general, blood flows slowly in capillaries to allow time for exchange of nutrients and wastes. In the vasa recta particularly, this rate of flow is important for two additional reasons. The flow must be slow to allow blood cells to lose and regain water without either crenating or bursting. Second, a rapid flow would remove too much Na + and urea, destroying the osmolar gradient that is necessary for the recovery of solutes and water. Thus, by flowing slowly to preserve the countercurrent mechanism, as the vasa recta descend, Na + and urea are freely able to enter the capillary, while water freely leaves; as they ascend, Na + and urea are secreted into the surrounding medulla, while water reenters and is removed.

Watch this video to learn about the countercurrent multiplier system.

Reabsorption and secretion in the distal convoluted tubule

Approximately 80 percent of filtered water has been recovered by the time the dilute forming urine enters the DCT. The DCT will recover another 10–15 percent before the forming urine enters the collecting ducts. Aldosterone increases the amount of Na + /K + ATPase in the basal membrane of the DCT and collecting duct. The movement of Na + out of the lumen of the collecting duct creates a negative charge that promotes the movement of Cl out of the lumen into the interstitial space by a paracellular route across tight junctions. Peritubular capillaries receive the solutes and water, returning them to the circulation.

Cells of the DCT also recover Ca ++ from the filtrate. Receptors for parathyroid hormone (PTH) are found in DCT cells and when bound to PTH, induce the insertion of calcium channels on their luminal surface. The channels enhance Ca ++ recovery from the forming urine. In addition, as Na + is pumped out of the cell, the resulting electrochemical gradient attracts Ca ++ into the cell. Finally, calcitriol (1,25 dihydroxyvitamin D, the active form of vitamin D) is very important for calcium recovery. It induces the production of calcium-binding proteins that transport Ca ++ into the cell. These binding proteins are also important for the movement of calcium inside the cell and aid in exocytosis of calcium across the basolateral membrane. Any Ca ++ not reabsorbed at this point is lost in the urine.

Collecting ducts and recovery of water

Solutes move across the membranes of the collecting ducts, which contain two distinct cell types, principal cells and intercalated cells. A principal cell    possesses channels for the recovery or loss of sodium and potassium. An intercalated cell    secretes or absorbs acid or bicarbonate. As in other portions of the nephron, there is an array of micromachines (pumps and channels) on display in the membranes of these cells.

Questions & Answers

what usually cause blood pressurae
Abdullateef Reply
too much salt in the diet
Abuusu
older age
Abuusu
Even family history of high blood pressure
Abuusu
explain the cellular mechanism that produces tetanus and summation
Jenica Reply
epithelial cells polerity
jitendra Reply
tissues
Deepak
demonstrate the fluid replacement in the body
John Reply
the red blood cells is in the long bones or flat bones?
isbii
as age increases, the bone elongates .. will the joint vanish?
Sushruth Reply
what is anatomy?
Ivy Reply
structure
Allonda
discuss the organization of the body
Mwila Reply
explain the cellular mechanism that produces tetanus and summation
Chayanne Reply
explain why the muscle doesn't respond to low stimulus voltages
Chayanne
how would muscle contractions be affected if skeletal muscle fibers did have T - tubules?
Chayanne
tetanus is a disease caused by a bacteria causing rigidity and spasms of volutary muscles.. there is a prolonged construction of muscles caused by repeated stimuli
Marcus
muscles follow the "all or none law" when it comes to reponse to stimuli... muscle construction would have been affected because the T tubules are the conducting tracts that transport the or move the action potential in deporalizing the other parts of cell hence the muscle wont act as a single cell
Marcus
Skeletal muscle fibers do have t tubules that's how action potential propagates to spread throughout the muscle. Tetanus production is a phenomenon which is better explained in time rather then cellularly. Action potentials either separated in time or space are summated on the muscle and
Vikas
When the stimulus frequency hits more than 25 the individual twitches from the fibers summate and the muscle as a whole contracts. Cellulary, a good amount of calcium needs to be accumulated as is done by twitches adding together.
Vikas
what is the names of tarsus?
Fathia Reply
the region of the foot containing the seven tarsal bones.
Manja
the tarsal bones
Marcus
how the valves keep the blood moving in one direction?
Nonie Reply
They open and close during blood circulation,
Denis
Then valve open labb sound and valve close dabb sound
HARDIK
The valves for example the semilunar valves act to prevent back flow of blood from arteries to ventricles during ventricular diastole and help to maintain pressure on the major arteries .The aortic semilunar valve separate the left ventricle from opening of the aorta.
Denis
thank you
Nonie
😷
HARDIK
hi
Shakir
hello
Manja
Yes
kannan
what are estrogen and progesterone ? and their functions
Emmanuel
it's a body hormones and this is spread by women and it's can help to reproduction system...
HARDIK
yhe I also wana know
Lemasyanji
can we introduce ourselves and share contact?
Emmanuel
🤔
HARDIK
thanks
Emmanuel
i want ti study medicine.. what are the main course?
Emmanuel
Progesterone helps to maintain the endometrium wall which is later shed out of the body during the menstrual cycle
Smisha
Estrogen is another ovarian hormone which helps the primary follicle to develop into graafian follicle and cause ovulation
Smisha
what is decstro cardiac
priyanshi
Right sided heart in a guy
Vikas
Dextrocardia is a condition where the. heart lies in the right side of the thorax instead of the left and it occurs when the heart loops to the left instead of the right.
Idoko
hii
Vikas
can any talk me a scope of anatomy and physiology
Vikas
please
Vikas
It has valves that OPEN and close during circulation
xiao
What does the Thyroid gland means
Solomon Reply
It's a gland in your neck produces thyroid hormone maintains body metabolism
Vikas
how many joints are in the human foot?
Roghayeh Reply
I believe that is 33 joints
Ana
26 bones and 33 joints.
Amin
thank u.
Roghayeh
thanks
antouman
what is the nerve supply of orbicularis oculi?
Juliet Reply
buccal branch of the facial nerve (cranial nerve VII).
Jeremiah
thanks a lot
antouman
water is the compound formed when oxygen and hydrogen reacts together
Kabwe
what is chordinae tendinae
Aryan
Structures that keep the heart valves shut together n its "chordae"
Vikas
what is agglutination
Aryan
please can challenging questions be given out, and not what we already know, feel free to share hidden knowledge
barbie
people have usually have 2 kidneys.how are these located?
Roghayeh
what is the Function of Thyroid gland in our body
Fahim Reply
regulates body metabolic rate
Arif
describe blood cells
Sumanraj Reply
1.we have white blood 2.red blood. Blood I a platelate 3.plasma
UMAR
right
chimdinma

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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