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Synthesis of vitamin d

This illustration resembles a flow chart. It begins with the sun shining on a silhouette of a man. One arrow leads from the sun to the man’s skin, stating that Vitamin D is manufactured in the skin after the absorption of sunlight. Another arrow points into the man’s mouth and states that Vitamin D is ingested through food and supplements, absorbed by the intestines, and carried to the liver via the bloodstream. A call out of the liver states that, in the liver, Vitamin D turns into 25 (OH) D, also known as calcidiol, the primary form of circulating Vitamin D. Another callout of the right kidney states that, in the kidneys, Vitamin D is transformed into 1 25 OH (D2). This is also known as calcitriol, a biologically active form of Vitamin D. The synthesis of Vitamin D facilitates calcium absorption from the small intestine, calcium re-absorption from the kidneys, and the rebuilding of bone tissue.
Sunlight is one source of vitamin D.

Other nutrients

Vitamin K also supports bone mineralization and may have a synergistic role with vitamin D in the regulation of bone growth. Green leafy vegetables are a good source of vitamin K.

The minerals magnesium and fluoride may also play a role in supporting bone health. While magnesium is only found in trace amounts in the human body, more than 60 percent of it is in the skeleton, suggesting it plays a role in the structure of bone. Fluoride can displace the hydroxyl group in bone’s hydroxyapatite crystals and form fluorapatite. Similar to its effect on dental enamel, fluorapatite helps stabilize and strengthen bone mineral. Fluoride can also enter spaces within hydroxyapatite crystals, thus increasing their density.

Omega-3 fatty acids have long been known to reduce inflammation in various parts of the body. Inflammation can interfere with the function of osteoblasts, so consuming omega-3 fatty acids, in the diet or in supplements, may also help enhance production of new osseous tissue. [link] summarizes the role of nutrients in bone health.

Nutrients and Bone Health
Nutrient Role in bone health
Calcium Needed to make calcium phosphate and calcium carbonate, which form the hydroxyapatite crystals that give bone its hardness
Vitamin D Needed for calcium absorption
Vitamin K Supports bone mineralization; may have synergistic effect with vitamin D
Magnesium Structural component of bone
Fluoride Structural component of bone
Omega-3 fatty acids Reduces inflammation that may interfere with osteoblast function

Hormones and bone tissue

The endocrine system produces and secretes hormones, many of which interact with the skeletal system. These hormones are involved in controlling bone growth, maintaining bone once it is formed, and remodeling it.

Hormones that influence osteoblasts and/or maintain the matrix

Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth in several ways. It triggers chondrocyte proliferation in epiphyseal plates, resulting in the increasing length of long bones. GH also increases calcium retention, which enhances mineralization, and stimulates osteoblastic activity, which improves bone density.

GH is not alone in stimulating bone growth and maintaining osseous tissue. Thyroxine, a hormone secreted by the thyroid gland promotes osteoblastic activity and the synthesis of bone matrix. During puberty, the sex hormones (estrogen in girls, testosterone in boys) also come into play. They too promote osteoblastic activity and production of bone matrix, and in addition, are responsible for the growth spurt that often occurs during adolescence. They also promote the conversion of the epiphyseal plate to the epiphyseal line (i.e., cartilage to its bony remnant), thus bringing an end to the longitudinal growth of bones. Additionally, calcitriol, the active form of vitamin D, is produced by the kidneys and stimulates the absorption of calcium and phosphate from the digestive tract.

Questions & Answers

write short notes on ligaments,curves and moverment of vertebral column.
mutesi Reply
what is the Analysis
ROHIT Reply
what is Anatomy
ROHIT Reply
it's a organs and bouns reading
AJITH
Cutting Up
Nonie
Cutting Up
Nonie
to dissect
Nonie
what usually cause blood pressurae
Abdullateef Reply
too much salt in the diet
Abuusu
older age
Abuusu
Even family history of high blood pressure
Abuusu
yes
Yaqub
too much salt in the diet
Yaqub
stress is the leading factor
Richard
smoking and too much alcohol consumption
Annu
obesity can also cause hypertension
Yaqub
high temperature of the body high salt of the body
Drs
how does the temperature affect the blood pressure?
Chidiebere
sex
Onavwie
What sex.?
Arshad
Male
Vikas
i mearnt gender,there's increased blood pressure in male than female
Onavwie
guys, read the question, involuntary pumping of heart causes the blood pressure in the arteries, he has not asked about high or low BP.
Jess
explain the cellular mechanism that produces tetanus and summation
Jenica Reply
epithelial cells polerity
jitendra Reply
tissues
Deepak
demonstrate the fluid replacement in the body
John Reply
the red blood cells is in the long bones or flat bones?
isbii
as age increases, the bone elongates .. will the joint vanish?
Sushruth Reply
what is anatomy?
Ivy Reply
structure
Allonda
discuss the organization of the body
Mwila Reply
explain the cellular mechanism that produces tetanus and summation
Chayanne Reply
explain why the muscle doesn't respond to low stimulus voltages
Chayanne
how would muscle contractions be affected if skeletal muscle fibers did have T - tubules?
Chayanne
tetanus is a disease caused by a bacteria causing rigidity and spasms of volutary muscles.. there is a prolonged construction of muscles caused by repeated stimuli
Marcus
muscles follow the "all or none law" when it comes to reponse to stimuli... muscle construction would have been affected because the T tubules are the conducting tracts that transport the or move the action potential in deporalizing the other parts of cell hence the muscle wont act as a single cell
Marcus
Skeletal muscle fibers do have t tubules that's how action potential propagates to spread throughout the muscle. Tetanus production is a phenomenon which is better explained in time rather then cellularly. Action potentials either separated in time or space are summated on the muscle and
Vikas
When the stimulus frequency hits more than 25 the individual twitches from the fibers summate and the muscle as a whole contracts. Cellulary, a good amount of calcium needs to be accumulated as is done by twitches adding together.
Vikas
what is the names of tarsus?
Fathia Reply
the region of the foot containing the seven tarsal bones.
Manja
the tarsal bones
Marcus
how the valves keep the blood moving in one direction?
Nonie Reply
They open and close during blood circulation,
Denis
Then valve open labb sound and valve close dabb sound
HARDIK
The valves for example the semilunar valves act to prevent back flow of blood from arteries to ventricles during ventricular diastole and help to maintain pressure on the major arteries .The aortic semilunar valve separate the left ventricle from opening of the aorta.
Denis
thank you
Nonie
😷
HARDIK
hi
Shakir
hello
Manja
Yes
kannan
what are estrogen and progesterone ? and their functions
Emmanuel
it's a body hormones and this is spread by women and it's can help to reproduction system...
HARDIK
yhe I also wana know
Lemasyanji
can we introduce ourselves and share contact?
Emmanuel
🤔
HARDIK
thanks
Emmanuel
i want ti study medicine.. what are the main course?
Emmanuel
Progesterone helps to maintain the endometrium wall which is later shed out of the body during the menstrual cycle
Smisha
Estrogen is another ovarian hormone which helps the primary follicle to develop into graafian follicle and cause ovulation
Smisha
what is decstro cardiac
priyanshi
Right sided heart in a guy
Vikas
Dextrocardia is a condition where the. heart lies in the right side of the thorax instead of the left and it occurs when the heart loops to the left instead of the right.
Idoko
hii
Vikas
can any talk me a scope of anatomy and physiology
Vikas
please
Vikas
It has valves that OPEN and close during circulation
xiao
What does the Thyroid gland means
Solomon Reply
It's a gland in your neck produces thyroid hormone maintains body metabolism
Vikas
how many joints are in the human foot?
Roghayeh Reply
I believe that is 33 joints
Ana
26 bones and 33 joints.
Amin
thank u.
Roghayeh
thanks
antouman

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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