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Drosophila melanogaster

D. melanogaster

The drosophila (fruit fly) genome is 180Mb in size and contains approx. 13,600 genes (Genie and Genescan were used to predict genes). The somewhat smaller C. elegans genome actually contains more genes than the Drosophila genome, although the functional diversity between the two species appears to be very similar. The Drosophila genome was published in March of 2000 (Science, 24 March 2000), a few years after the C. elegans genome was initially released. The genome contains 3 autosomal chromosomes (numbered 2-4), and one X chromosome. Each drosophila gene contains on average 4 exons of approx. 750bp a piece. Intron size is highly variable and can range from 40bp to more than 70kb. Introns and exons are both predicted to occupy around 20Mb of sequence.

Homo sapiens

Homo sapiens

Sequencing of the human genome was first formally proposed in 1985, but at the time the idea was met with mixed reactions in the scientific community. Then in1990 the Human Genome Project (HGP), under the direction by the N.I.H. and the Dept. of Energy, launched a 15-year, $3 billion plan for sequencing the complete human genome. Their progress was slow however and the HGP did not appear to be on pace to finish by the projected date in 2005. Half way through their planned time period, in early 1998, the HGP had sequenced less than 5% of the entire genome.

Then, in the same year that the HGP was reevaluating its progress, Celera, headed by Craig Venter, announced its intention to sequence the entire human genome over a three year period. After cutting their teeth on the Drosophila genome (which was done in collaboration with Gerald Rubin and the Berkley Drosophila Genome Project), Celera initiated the whole-genome shotgun sequencing of the human genome on September 8th, 1999. Less than a year later, on 17 June 2000, the first draft of the genome was completed. Today 99.9% of the human genome is 'finished', meaning less than 1 bp error per 10,000 base pairs.

The method Celera used, termed shotgun sequencing, is conceptually straightforward, but requires large amounts of computer processing power to complete. The protocol (in great oversimplification) is as follows: 1) cut up the genomic DNA into small pieces of known and regular size, 2) clone the pieces of genomic DNA into plasmids for purification and amplification purposes, 3) randomly sequence the DNA fragments from the plasmids while screening the results for contamination, 4) and then load the whole sequenced mess into the computer and let the computer sort it all out. The computer essentially plays a giant matching game building up larger and larger overlapping sequences until the whole genome is finally laid out in entirety. The process is, of course, not nearly this simple. One major complication worth mentioning is that the human genome is particularly replete with repeat sequences that could easily create numerous misleading matches. Computing the set of all overlaps required approx. 10,000 CPU hours on a suite of four-processor Alpha SMPs with 4 gigabytes of RAM (4-5 days in elapsed time using 40 such machines).

Questions & Answers

Define Intelligence.
Emma Reply
what does BS Psychology do? or what jobs are available?
Samwan Reply
Hello guys good morning
Tanam Reply
gud mornin
Good evening, I hope everyone is having a great day! :)
Fine namira
What makes people with sickle cell not fat does the illness damage their body?
Normally, RBCs are shaped like discs, which gives them the flexibility to travel through even the smallest blood vessels. However, with this disease, the RBCs have an abnormal crescent shape resembling a sickle. This makes them sticky and rigid and prone to getting trapped in small vessels
this leads to blood not reaching much to parts, leading to anaemia. and hence them not being able to gain any weight
nice I see
I have a question regarding counselling.
A teenaged girl comes up to a therapist and speaks about her issues that she is having with her mother, for instance, she wants something from her mother ( attention, care and love) that is she is deprived of. How do we counsel her? what do we tell her in such a situation where she cannot directly
convey her needs to her mother.
natural law therapy
first, like, try to get to know how is her conversational relationship with her mother. that if her mother blatantly ignores her, or doesn't pay much attention or what. also try to pry if their relationship is strained or okay okay or good.
your next course of action can only be decided by the answer to this
if her mother is like, not that good a parent, try to bring her in in therapy as well, if she's an okay okay one, have her and the girl sit down and talk in front of you. and if she's a good parent, all you have to do is encourage the girl to talk.
and also talk to the mother explaining​ that a healthy discussion or even a simple heart to heart with children is a must
Alright, thankyou so much. :)
What made psychology be studied under philosophy
fatima Reply
..Cos everything begins with the love of Wisdom
first ,explain what is psychology and philosophy .Then you state and explain the various reasons for which psychology was studied under philosophy.
Then you give a suitable conclusion.
please can anyone help me with different between Cognitive and Personality structure
cognitive deals with mind and metal while personality deals with physical actions
cognitive is nothing but our way of processing the information....were as personality is totally different ....that it relates to our environment....that means how we behave according to our circumstances...
now are u clear
what is psychology
Beatriz Reply
Psychology is the study of soul
scientific study of mind and behavior
a real life example of humanistic model
Alexsus Reply
what is a linear relationship
Happy Reply
directly related. like if one factor changes, so will the other
explain the process of visua sensation
David Reply
Sensation is defined as the stimulation of sense organs Visual sensation is a physiological process which means that it is the same for everyone. We absorb energy such as electro magnetic energy (light) or sound waves by sensory organs such as eyes.
what is selective attention?
Happy what did you say visual sensation is ?
please make your explanation clear for us
you mean you experience sensation by what you see..
I thought it was by what your five senses interpreted
visual has to do with the eyes alone
sensory has to do with all the sense organs ranging from the eyes,nose, skin,tongue and ear
selective attention is focusing on a particular stimulus out of myriads of stimuli
visual sensation in simple terms is standing from far it seems to assume that the trees are emerged but when you get they totally separated
seeing the trees been emerged is the visual sensation.That is my understanding, you can also find out
a woman watch me all time why
Janak Reply
because it is hard to test alot of things in it empiricaly
Ahmed Reply
good Morning, I want someone to give me a lecture on levels of conscious
Tebukoza Reply
why is psyche represented as a butterfly?
Gabriella Reply
Psyche's mythological imagery in ancient art is represented with butterfly wings, amply depicted in pottery as well. ... The metamorphosis of the butterfly inspired many to use butterflies as a symbol of the soul's exit from the body. Thus, the myth of Psyche concomitantly signifies soul and butterf
ok thanks
On what basis do people argue that genes do not set limits on a person's potential?
Shruti Reply
The Nature-Nature Thingy
Nature vs nurture
well, going by Polygenic Hypothesis formulated in a genome-wide association study (GWAS), each (even all) gene(s) affects every complex trait. from physical to even one's mental growth (though it's still debatable).
Like you know, the selfish gene, like genes passed on to generation after generation​; and if a person with a certain gene arrangement pattern meets someone remotely resembling even a part of it, he/she'll automatically behave selflessly towards the other person.
somewhat linking to the idea of soulmates, and Plato's idea of conjoint men and women who were split by God and hence strive to become one yet again. (I know I'm wandering away from psychology here)
But IQ is affected by both genes and environment.
"Other studies at the world-leading Minnesota Center for Twin and Family Research suggest that many of our traits are more than 50% inherited, including obedience to authority, vulnerability to stress, and risk-seeking. "
as for effect of the environment, study of epigenetics shows that how many inherited traits only get “switched on” in certain environments.
BUT, "Various options are pencilled in by our genes, and our life experiences determine which get inked." That is, what gets 'unlocked' depends on our experience and environment factor.
like determining if a person will be introvert or extrovert, by just observing his parents is not enough. though it does contribute a major part.
so, I'd like to go against your question (somewhat) and say, genes do set limitations, but what some genes only 'unlock' under certain circumstances and environment, so they don't limit it totally
hope it helped. @ me (CK) if any doubts or queries remain
Hi, I have completed my Engineering with MBA in HR, and I want to pursue my career in field related to psychology. Is it possible to study psychology and pursue my dream.
Aparnaa Reply
You can but you'll have to start from FYBA again
Oh! hmm thank you.
Look into getting a doctorate in industrial/organizational psychology. There are myriad fields within psychology; which one are you pursuing?
something like counselling!
if you want to be a licensed professional counselor, you need to get a master of arts degree in counseling. It takes about two years to complete. you will have a practicum/internship as well within your coursework. Before you apply for a degree, find out your states requirements about licensure.
Hmm i will check the details and thank you so much!
am a a student clinical officer
David Reply
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