• Card 11 / 32: Compare and contrast the signaling events involved with the second messengers cAMP and IP3.

    Answer:
    In both cAMP and IP3-calcium signaling, a hormone binds to a cell membrane hormone receptor that is coupled to a G protein. The G protein becomes activated when the hormone binds. In the case of cAMP signaling, the activated G protein activates adenylyl cyclase, which causes ATP to be converted to cAMP. This second messenger can then initiate other signaling events, such as a phosphorylation cascade. In the case of IP3-calcium signaling, the activated G protein activates phospholipase C, which cleaves a membrane phospholipid compound into DAG and IP3. IP3 causes the release of calcium, another second messenger, from intracellular stores. This causes further signaling events.

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Anatomy & Physiology 17 Endocrine System Essay

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Attribution:  OpenStax College. Anatomy & Physiology, OpenStax-CNX Web site. http://cnx.org/content/col11496/1.6/, Jun 11, 2014
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