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Neutrophils and eosinophils are particularly important leukocytes that engulf large pathogens, such as bacteria and fungi. A mast cell    is a leukocyte that produces inflammatory molecules, such as histamine, in response to large pathogens. A basophil    is a leukocyte that, like a neutrophil, releases chemicals to stimulate the inflammatory response as illustrated in [link] . Basophils are also involved in allergy and hypersensitivity responses and induce specific types of inflammatory responses. Eosinophils and basophils produce additional inflammatory mediators to recruit more leukocytes. A hypersensitive immune response to harmless antigens, such as in pollen, often involves the release of histamine by basophils and mast cells.

 Illustration shows a capillary near the surface of skin that has a cut in it. Bacteria have penetrated the skin around the cut. In response, mass cells in the lower part of the skin tissue release histamines, and dendritic cells release cytokines. The histamines cause the capillary to become permeable. Neutrophils and monocytes exit the capillary into the damaged skin. Both the neutrophil and macrophage release cytokines and consumes bacteria by phagocytosis.
In response to a cut, mast cells secrete histamines that cause nearby capillaries to dilate. Neutrophils and monocytes leave the capillaries. Monocytes mature into macrophages. Neutrophils, dendritic cells and macrophages release chemicals to stimulate the inflammatory response. Neutrophils and macrophages also consume invading bacteria by phagocytosis.

Cytokines also send feedback to cells of the nervous system to bring about the overall symptoms of feeling sick, which include lethargy, muscle pain, and nausea. These effects may have evolved because the symptoms encourage the individual to rest and prevent them from spreading the infection to others. Cytokines also increase the core body temperature, causing a fever, which causes the liver to withhold iron from the blood. Without iron, certain pathogens, such as some bacteria, are unable to replicate; this is called nutritional immunity.

Watch this 23-second stop-motion video showing a neutrophil that searches for and engulfs fungus spores during an elapsed time of about 79 minutes.

Natural killer cells

Lymphocytes are leukocytes that are histologically identifiable by their large, darkly staining nuclei; they are small cells with very little cytoplasm, as shown in [link] . Infected cells are identified and destroyed by natural killer (NK) cells , lymphocytes that can kill cells infected with viruses or tumor cells (abnormal cells that uncontrollably divide and invade other tissue). T cells and B cells of the adaptive immune system also are classified as lymphocytes. T cells are lymphocytes that mature in the thymus gland, and B cells are lymphocytes that mature in the bone marrow. NK cells identify intracellular infections, especially from viruses, by the altered expression of major histocompatibility class (MHC) I molecules on the surface of infected cells. MHC I molecules are proteins on the surfaces of all nucleated cells, thus they are scarce on red blood cells and platelets which are non-nucleated. The function of MHC I molecules is to display fragments of proteins from the infectious agents within the cell to T-cells; healthy cells will be ignored, while “non-self” or foreign proteins will be attacked by the immune system. MHC II molecules are found mainly on cells containing antigens (“non-self proteins”) and on lymphocytes. MHC II molecules interact with helper T-cells to trigger the appropriate immune response, which may include the inflammatory response.

Questions & Answers

what is abiotic and biotic factors?
Hira Reply
which of the following shows the correct sequence of the cell cycle
Kameishia Reply
who is name virus
Shivam Reply
centromere consist of
Shivam
meeting point of two chromatids
Cffrrcvccgg
Explain the function of nematocysts in cnidarians?
Israel Reply
The nemotocyst is used by Cnidarians (hydra, jellyfish, sea anemones) to sting their prey and any threatening enemy.
Lee
photosynthesis in plants is an example of what ? (a) excretion (b) irritability (c) nutrition (d) reproduction
Lee Reply
If a Hox 13 gene in a mouse was replaced with a Hox 1 gene, how might this alter animal development?
Israel Reply
Which of the following organisms is most likely to be a diploblast?
Israel
what are reactions of photosynthesis?
Maria Reply
what are the probabilities of blood genotypes for the offspring from a cross between a mother lAlA blood and a father with lBi blood?
dayana Reply
what is matter
Emmanuel Reply
matter is anything that has mass and can occupied space
Alice
weight
Alice
example of matter
Oyekemi
You serves as an example of matter Because matter is anything that has mass and occupy space e.g man and every other things that exist on earth.. So think of every other things around you ...
Biola
and you too
Oyekemi
We generally
Biola
What is ecological management
Oyekemi
how the kidney functions as osmoregulatory organ
Sam Reply
That true
Banda
what is the major connection for sugars in glycolysis?
Ibrahim Reply
Simple term of science
Palesa Reply
what does it mean
gopal
it's means what do u know about biology?
Phathu
what is immunisation
Melysa
the action of making a person immune to infections ,for immunisation
Kalia
what is the biology? what do you know about biology
Phathu Reply
biology is the study of living organisms, divided into many specialized fields that cover their morphology, physiology, anatomy, behavior, origin, and distribution.
Julia
The study of all aspects of life. The study of all living organisms (such as animal cells and plant cells) in greater detail (their structure and how they function). It's a very broad science.
juanita
what is prokaryotic
Bhaskar Reply
what is pathogens
Bhaskar
pathogens are a bacterium, virus, or other microorganism that can cause disease.
Lee
transistion metals....
Wasik Reply

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Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
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