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Ketone oxidation

This figure shows the reactions in which ketone is oxidized to acetyl-CoA.
When glucose is limited, ketone bodies can be oxidized to produce acetyl CoA to be used in the Krebs cycle to generate energy.

Lipogenesis

When glucose levels are plentiful, the excess acetyl CoA generated by glycolysis can be converted into fatty acids, triglycerides, cholesterol, steroids, and bile salts. This process, called lipogenesis    , creates lipids (fat) from the acetyl CoA and takes place in the cytoplasm of adipocytes (fat cells) and hepatocytes (liver cells). When you eat more glucose or carbohydrates than your body needs, your system uses acetyl CoA to turn the excess into fat. Although there are several metabolic sources of acetyl CoA, it is most commonly derived from glycolysis. Acetyl CoA availability is significant, because it initiates lipogenesis. Lipogenesis begins with acetyl CoA and advances by the subsequent addition of two carbon atoms from another acetyl CoA; this process is repeated until fatty acids are the appropriate length. Because this is a bond-creating anabolic process, ATP is consumed. However, the creation of triglycerides and lipids is an efficient way of storing the energy available in carbohydrates. Triglycerides and lipids, high-energy molecules, are stored in adipose tissue until they are needed.

Although lipogenesis occurs in the cytoplasm, the necessary acetyl CoA is created in the mitochondria and cannot be transported across the mitochondrial membrane. To solve this problem, pyruvate is converted into both oxaloacetate and acetyl CoA. Two different enzymes are required for these conversions. Oxaloacetate forms via the action of pyruvate carboxylase, whereas the action of pyruvate dehydrogenase creates acetyl CoA. Oxaloacetate and acetyl CoA combine to form citrate, which can cross the mitochondrial membrane and enter the cytoplasm. In the cytoplasm, citrate is converted back into oxaloacetate and acetyl CoA. Oxaloacetate is converted into malate and then into pyruvate. Pyruvate crosses back across the mitochondrial membrane to wait for the next cycle of lipogenesis. The acetyl CoA is converted into malonyl CoA that is used to synthesize fatty acids. [link] summarizes the pathways of lipid metabolism.

Lipid metabolism

This figure shows the different reactions that take place for lipid metabolism.
Lipids may follow one of several pathways during metabolism. Glycerol and fatty acids follow different pathways.

Chapter review

Lipids are available to the body from three sources. They can be ingested in the diet, stored in the adipose tissue of the body, or synthesized in the liver. Fats ingested in the diet are digested in the small intestine. The triglycerides are broken down into monoglycerides and free fatty acids, then imported across the intestinal mucosa. Once across, the triglycerides are resynthesized and transported to the liver or adipose tissue. Fatty acids are oxidized through fatty acid or β-oxidation into two-carbon acetyl CoA molecules, which can then enter the Krebs cycle to generate ATP. If excess acetyl CoA is created and overloads the capacity of the Krebs cycle, the acetyl CoA can be used to synthesize ketone bodies. When glucose is limited, ketone bodies can be oxidized and used for fuel. Excess acetyl CoA generated from excess glucose or carbohydrate ingestion can be used for fatty acid synthesis or lipogenesis. Acetyl CoA is used to create lipids, triglycerides, steroid hormones, cholesterol, and bile salts. Lipolysis is the breakdown of triglycerides into glycerol and fatty acids, making them easier for the body to process.

Questions & Answers

what organelles controls protein synthesis?
Katie Reply
Ribosome
AMEL
hmm...the ribosomes?
Fatukasi
ribosome
adam
Ribosome
Opara
Ribosome
Saifkhan
ribosome
DR
ribosome
ELIZABETH
are ribisomes made in the rRNA?
Lola
nop they are produced by cells of Nucleolus
adam
Is there anything about nerve and muscle physiology?
AMEL Reply
how many types of epithelial tissues do we have
Benedicta Reply
Epithelial tissues are grouped in two ways.. ●Based on the number of layers.(Simple and stratified ) ●Based of their shapes(Squamous,Cuboidal and columnar) Also we can have a combination of the two,say,simple Squamous
Prince
awww thanks dearie😊😊😊💖
Benedicta
describe the function and structure of blood
Belindah Reply
It has four main components: plasma, red blood cells, white blood cells, and platelets. Blood has many different functions, including: transporting oxygen and nutrients to the lungs and tissues.
Arlena
well answered arlena.. #thumbs up#
Fatukasi
have u some prepared MCQs on CNS and Special senses physiology?
dr
Anyone got the human heart labelled diagram
Sawmtei
you can download from Google... I don't think it's possible to share docs or files here
Fatukasi
ok thanks
Sawmtei
you're welcome..
Fatukasi
thanks
dr
Thank you
Drs
what's an easy way of knowing the different structures of tissues what they do and where their found
Lola
are you know function of the blood?
Drs
to carry nutrients to parts of the body
Lola
well Lola the easiest way is to attributes the tissues based on their funcs(especially those with similar funcs)..you can create your own mnemonics that will help you rmba em..and the a random reading.. it helps you retain em better
Fatukasi
and try random reading*
Fatukasi
ok thanks
Lola
funtction of WBCs
DR
bone tissue
Waqar
identy the vein and arteries of coronary circulation
abdifatah Reply
to be a nurse a doctor or just to understand the body
Drew Reply
what is the basic part of life
Drew
cell remains the basic unit of life...
Fatukasi
The coronary arteries branches off of what
Ada Reply
gh
Asad
rephrase your question
Fatukasi
Discuss Active Myosin contraction theory
Xavier Reply
What is dissected?
Jc Reply
It is a minute and detailed analysis.."dissection"rather..
Kabwe
what is the net charge on both atoms of hydrogen and helium?
Brianna Reply
hii
Shubham
hii
Maddy
Muche kuch bhi samaz me nhi aa rha he
Shubham
kya samaj nahii Aa raha hai
Maddy
What is homeostasis?
Xavier Reply
it is tha condition of equilibrium in body is internal invorment
Ravi
it is a dynamic condition
Ravi
it is the tendency towards a relatively stable equilibrium between interdependent elements.
Kyekyelle
what is connective tissue
sourav Reply
it is tissue that connects, binds, supports and separates
Brenda
Just as it name it Connects and helps to attach parts
Xavier
tissue in a connects to tha bones
naime
who many days does the sperm stays before fertilizing
Ferlin Reply
72hours
Opara
you mean the durability of sperm In the oviduct?
Fatukasi
What is the meddle cranial fossa?
Margret Reply
What is the meddle cranial fossa.
Margret Reply

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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