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The ph scale

This figure shows a vertical arrow with the top half showing the basic scale and the bottom half showing the acidic scale. Different chemicals and their pH are also shown.

Buffers

The pH of human blood normally ranges from 7.35 to 7.45, although it is typically identified as pH 7.4. At this slightly basic pH, blood can reduce the acidity resulting from the carbon dioxide (CO 2 ) constantly being released into the bloodstream by the trillions of cells in the body. Homeostatic mechanisms (along with exhaling CO 2 while breathing) normally keep the pH of blood within this narrow range. This is critical, because fluctuations—either too acidic or too alkaline—can lead to life-threatening disorders.

All cells of the body depend on homeostatic regulation of acid–base balance at a pH of approximately 7.4. The body therefore has several mechanisms for this regulation, involving breathing, the excretion of chemicals in urine, and the internal release of chemicals collectively called buffers into body fluids. A buffer    is a solution of a weak acid and its conjugate base. A buffer can neutralize small amounts of acids or bases in body fluids. For example, if there is even a slight decrease below 7.35 in the pH of a bodily fluid, the buffer in the fluid—in this case, acting as a weak base—will bind the excess hydrogen ions. In contrast, if pH rises above 7.45, the buffer will act as a weak acid and contribute hydrogen ions.

Homeostatic imbalances

Acids and bases

Excessive acidity of the blood and other body fluids is known as acidosis. Common causes of acidosis are situations and disorders that reduce the effectiveness of breathing, especially the person’s ability to exhale fully, which causes a buildup of CO 2 (and H + ) in the bloodstream. Acidosis can also be caused by metabolic problems that reduce the level or function of buffers that act as bases, or that promote the production of acids. For instance, with severe diarrhea, too much bicarbonate can be lost from the body, allowing acids to build up in body fluids. In people with poorly managed diabetes (ineffective regulation of blood sugar), acids called ketones are produced as a form of body fuel. These can build up in the blood, causing a serious condition called diabetic ketoacidosis. Kidney failure, liver failure, heart failure, cancer, and other disorders also can prompt metabolic acidosis.

In contrast, alkalosis is a condition in which the blood and other body fluids are too alkaline (basic). As with acidosis, respiratory disorders are a major cause; however, in respiratory alkalosis, carbon dioxide levels fall too low. Lung disease, aspirin overdose, shock, and ordinary anxiety can cause respiratory alkalosis, which reduces the normal concentration of H + .

Metabolic alkalosis often results from prolonged, severe vomiting, which causes a loss of hydrogen and chloride ions (as components of HCl). Medications also can prompt alkalosis. These include diuretics that cause the body to lose potassium ions, as well as antacids when taken in excessive amounts, for instance by someone with persistent heartburn or an ulcer.

Chapter review

Inorganic compounds essential to human functioning include water, salts, acids, and bases. These compounds are inorganic; that is, they do not contain both hydrogen and carbon. Water is a lubricant and cushion, a heat sink, a component of liquid mixtures, a byproduct of dehydration synthesis reactions, and a reactant in hydrolysis reactions. Salts are compounds that, when dissolved in water, dissociate into ions other than H + or OH . In contrast, acids release H + in solution, making it more acidic. Bases accept H + , thereby making the solution more alkaline (caustic).

The pH of any solution is its relative concentration of H + . A solution with pH 7 is neutral. Solutions with pH below 7 are acids, and solutions with pH above 7 are bases. A change in a single digit on the pH scale (e.g., from 7 to 8) represents a ten-fold increase or decrease in the concentration of H + . In a healthy adult, the pH of blood ranges from 7.35 to 7.45. Homeostatic control mechanisms important for keeping blood in a healthy pH range include chemicals called buffers, weak acids and weak bases released when the pH of blood or other body fluids fluctuates in either direction outside of this normal range.

Questions & Answers

draw the male reproductive system
Jeremaih Reply
Explain how different foods can affect metabolism
Abraham Reply
what is Endocrine system?
Islam Reply
which secrete hormones and other products direct into the blood
Aadi
Cell is basic, structural and functional unit of life
Kabuja Reply
The cell is the structural and functional unit of all living organisms, and is sometimes called the "building block of life." Some organisms, such as bacteria, are unicellular, consisting of a single cell.
Br_
hi am new here..wish to join you in this conversation
Rachel
welcome Rachel am Brianito
hingi
hey
HALLELUYAH
can some one help
HALLELUYAH
what is the basic function of the lymphatic system
HALLELUYAH
The other main function is that of defense in the immune system. Lymph is very similar to blood plasma: it contains lymphocytes. It also contains waste products and cellular debris together with bacteria and proteins. Associated organs composed of lymphoid tissue are the sites of lymphocyte producti
Adnan
the function of lymphatic system are 1fluid balance 2 lipid absorption and 3 defence
Sidra
destroyed microognism
Usman
lymphatic systems main function is to transport lymph
Colleen
may i know the meaning of infestation of parasite?
Aminiely
Which of the following accurately describe external respirations
Robin Reply
different between anatomy and physiology
Samwel Reply
anatomy is the study of STRUCTURE of the body while physiology is the study of the function of the part of the body
Gborgbor
Anatomy deals with the structure and parts of the body while physiology is the function of the the body parts
Archie
not understanding what is a cell
Kesa Reply
its the fundamental unit of life or its the primary step in which two or more cell combine to form a tissue .
Sidra
Is the smallest structural and functional unit of life
Aliyu
cell is the basic you unit of life
Esther
what is osteomalàcia
Ellen Reply
what is hydroxyapitate
Ellen
Hydroxyapatite, also called hydroxylapatite, is a naturally occurring mineral form of calcium apatite with the formula Ca₅(PO₄)₃, but it is usually written Ca₁₀(PO₄)₆(OH)₂ to denote that the crystal unit cell comprises two entities. Hydroxyapatite is the hydroxyl endmember of the complex apatite gro
Br_
..up
Br_
what's the best way to memorize the terms and what it does
Kesa
osteomalacia is where inorganic or mineral which is calcium and phosphorus are removed from a bone....this will make the bone become flexible n in children is called ricket
Rashida
wat work does anatomy do in the hospital and can they get work fast after finishing
SULE Reply
what is the meaning of suture?
praba Reply
it is a protective layer of brain
Madhureddy
it is a kind of non movable joint present between skull bones
neha
suture is an example of fibrous joint and is synatrosys(is not movable)
Rashida
a junction between the sclerites of an imsect's body
Aadi
c organ,organ system, organism
Dorothy Reply
reproductive sytstem
Dorothy
describe structure and functions of spleen
Umesh Reply
why calcium does not prodecessed by biological process?
James Reply
when calcium isn't processed that becomes Calcium Homeostasis
Br_
follow this link for extra info on all processes of calcium including calcium metabolism > ***google.com/url?sa=t&source=web&rct=j&url=***opentextbc.ca/anatomyandphysiology/chapter/6-7-calcium-homeostasis-interactions-of-the-skeletal-system-and-other-organ-systems/&ved=2ahUKEwi06LTw-sP
Br_
Copy it and paste it on your browser url
Br_
What are the functions of batholine glan
Aliyu Reply
secretions
Sadia
Of what
Aliyu
what is pathogen
Nafiw Reply
hello
KING
an organism who invades the susceptible host
Mannu
what tenderness chord
KING
Tenderness A She tried to show me how to love D I bit her lips and bruised ...
Lovely
wha
Mannu
is not
KING
Pathogens are decease causing agents.... it can be a viral infection or fungai infection... thank u
Issah
laws of Gregor mended of genetics
Gloria
What is nosocomial
Bin
hospital accused infection.
Mailes
Hospital acquired infections
Clarice
Hospital acquired infections
Mailes
Hospital acquired infection
Vida

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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