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By the end of this section, you will be able to:
  • Describe how each of the following functions in the extrinsic control of GFR: renin–angiotensin mechanism, natriuretic peptides, and sympathetic adrenergic activity
  • Describe how each of the following works to regulate reabsorption and secretion, so as to affect urine volume and composition: renin–angiotensin system, aldosterone, antidiuretic hormone, and natriuretic peptides
  • Name and define the roles of other hormones that regulate kidney control

Several hormones have specific, important roles in regulating kidney function. They act to stimulate or inhibit blood flow. Some of these are endocrine, acting from a distance, whereas others are paracrine, acting locally.

Renin–angiotensin–aldosterone

Renin is an enzyme that is produced by the granular cells of the afferent arteriole at the JGA. It enzymatically converts angiotensinogen (made by the liver, freely circulating) into angiotensin I. Its release is stimulated by prostaglandins and NO from the JGA in response to decreased extracellular fluid volume.

ACE is not a hormone but it is functionally important in regulating systemic blood pressure and kidney function. It is produced in the lungs but binds to the surfaces of endothelial cells in the afferent arterioles and glomerulus. It enzymatically converts inactive angiotensin I into active angiotensin II. ACE is important in raising blood pressure. People with high blood pressure are sometimes prescribed ACE inhibitors to lower their blood pressure.

Angiotensin II is a potent vasoconstrictor that plays an immediate role in the regulation of blood pressure. It acts systemically to cause vasoconstriction as well as constriction of both the afferent and efferent arterioles of the glomerulus. In instances of blood loss or dehydration, it reduces both GFR and renal blood flow, thereby limiting fluid loss and preserving blood volume. Its release is usually stimulated by decreases in blood pressure, and so the preservation of adequate blood pressure is its primary role.

Aldosterone, often called the “salt-retaining hormone,” is released from the adrenal cortex in response to angiotensin II or directly in response to increased plasma K + . It promotes Na + reabsorption by the nephron, promoting the retention of water. It is also important in regulating K + , promoting its excretion. (This dual effect on two minerals and its origin in the adrenal cortex explains its designation as a mineralocorticoid.) As a result, renin has an immediate effect on blood pressure due to angiotensin II–stimulated vasoconstriction and a prolonged effect through Na + recovery due to aldosterone. At the same time that aldosterone causes increased recovery of Na + , it also causes greater loss of K + . Progesterone is a steroid that is structurally similar to aldosterone. It binds to the aldosterone receptor and weakly stimulates Na + reabsorption and increased water recovery. This process is unimportant in men due to low levels of circulating progesterone. It may cause increased retention of water during some periods of the menstrual cycle in women when progesterone levels increase.

Questions & Answers

write short notes on ligaments,curves and moverment of vertebral column.
mutesi Reply
cranial nerves notes
unimarwat
ok
Dems
what is the Analysis
ROHIT Reply
what is Anatomy
ROHIT Reply
it's a organs and bouns reading
AJITH
Cutting Up
Nonie
Cutting Up
Nonie
to dissect
Nonie
what usually cause blood pressurae
Abdullateef Reply
too much salt in the diet
Abuusu
older age
Abuusu
Even family history of high blood pressure
Abuusu
yes
Yaqub
too much salt in the diet
Yaqub
stress is the leading factor
Richard
smoking and too much alcohol consumption
Annu
obesity can also cause hypertension
Yaqub
high temperature of the body high salt of the body
Drs
how does the temperature affect the blood pressure?
Chidiebere
sex
Onavwie
What sex.?
Arshad
Male
Vikas
i mearnt gender,there's increased blood pressure in male than female
Onavwie
guys, read the question, involuntary pumping of heart causes the blood pressure in the arteries, he has not asked about high or low BP.
Jess
explain the cellular mechanism that produces tetanus and summation
Jenica Reply
epithelial cells polerity
jitendra Reply
tissues
Deepak
demonstrate the fluid replacement in the body
John Reply
the red blood cells is in the long bones or flat bones?
isbii
as age increases, the bone elongates .. will the joint vanish?
Sushruth Reply
what is anatomy?
Ivy Reply
structure
Allonda
discuss the organization of the body
Mwila Reply
explain the cellular mechanism that produces tetanus and summation
Chayanne Reply
explain why the muscle doesn't respond to low stimulus voltages
Chayanne
how would muscle contractions be affected if skeletal muscle fibers did have T - tubules?
Chayanne
tetanus is a disease caused by a bacteria causing rigidity and spasms of volutary muscles.. there is a prolonged construction of muscles caused by repeated stimuli
Marcus
muscles follow the "all or none law" when it comes to reponse to stimuli... muscle construction would have been affected because the T tubules are the conducting tracts that transport the or move the action potential in deporalizing the other parts of cell hence the muscle wont act as a single cell
Marcus
Skeletal muscle fibers do have t tubules that's how action potential propagates to spread throughout the muscle. Tetanus production is a phenomenon which is better explained in time rather then cellularly. Action potentials either separated in time or space are summated on the muscle and
Vikas
When the stimulus frequency hits more than 25 the individual twitches from the fibers summate and the muscle as a whole contracts. Cellulary, a good amount of calcium needs to be accumulated as is done by twitches adding together.
Vikas
what is the names of tarsus?
Fathia Reply
the region of the foot containing the seven tarsal bones.
Manja
the tarsal bones
Marcus
how the valves keep the blood moving in one direction?
Nonie Reply
They open and close during blood circulation,
Denis
Then valve open labb sound and valve close dabb sound
HARDIK
The valves for example the semilunar valves act to prevent back flow of blood from arteries to ventricles during ventricular diastole and help to maintain pressure on the major arteries .The aortic semilunar valve separate the left ventricle from opening of the aorta.
Denis
thank you
Nonie
😷
HARDIK
hi
Shakir
hello
Manja
Yes
kannan
what are estrogen and progesterone ? and their functions
Emmanuel
it's a body hormones and this is spread by women and it's can help to reproduction system...
HARDIK
yhe I also wana know
Lemasyanji
can we introduce ourselves and share contact?
Emmanuel
🤔
HARDIK
thanks
Emmanuel
i want ti study medicine.. what are the main course?
Emmanuel
Progesterone helps to maintain the endometrium wall which is later shed out of the body during the menstrual cycle
Smisha
Estrogen is another ovarian hormone which helps the primary follicle to develop into graafian follicle and cause ovulation
Smisha
what is decstro cardiac
priyanshi
Right sided heart in a guy
Vikas
Dextrocardia is a condition where the. heart lies in the right side of the thorax instead of the left and it occurs when the heart loops to the left instead of the right.
Idoko
hii
Vikas
can any talk me a scope of anatomy and physiology
Vikas
please
Vikas
It has valves that OPEN and close during circulation
xiao
What does the Thyroid gland means
Solomon Reply
It's a gland in your neck produces thyroid hormone maintains body metabolism
Vikas
how many joints are in the human foot?
Roghayeh Reply
I believe that is 33 joints
Ana
26 bones and 33 joints.
Amin
thank u.
Roghayeh
thanks
antouman

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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