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Microstructure of proteins

Proteins are polymers made up of nitrogen-containing monomers called amino acids. An amino acid    is a molecule composed of an amino group and a carboxyl group, together with a variable side chain. Just 20 different amino acids contribute to nearly all of the thousands of different proteins important in human structure and function. Body proteins contain a unique combination of a few dozen to a few hundred of these 20 amino acid monomers. All 20 of these amino acids share a similar structure ( [link] ). All consist of a central carbon atom to which the following are bonded:

  • a hydrogen atom
  • an alkaline (basic) amino group NH 2 (see [link] )
  • an acidic carboxyl group COOH (see [link] )
  • a variable group

Structure of an amino acid

This figure shows the structure of an amino acid.

Notice that all amino acids contain both an acid (the carboxyl group) and a base (the amino group) (amine = “nitrogen-containing”). For this reason, they make excellent buffers, helping the body regulate acid–base balance. What distinguishes the 20 amino acids from one another is their variable group, which is referred to as a side chain or an R-group. This group can vary in size and can be polar or nonpolar, giving each amino acid its unique characteristics. For example, the side chains of two amino acids—cysteine and methionine—contain sulfur. Sulfur does not readily participate in hydrogen bonds, whereas all other amino acids do. This variation influences the way that proteins containing cysteine and methionine are assembled.

Amino acids join via dehydration synthesis to form protein polymers ( [link] ). The unique bond holding amino acids together is called a peptide bond. A peptide bond    is a covalent bond between two amino acids that forms by dehydration synthesis. A peptide, in fact, is a very short chain of amino acids. Strands containing fewer than about 100 amino acids are generally referred to as polypeptides rather than proteins.

Peptide bond

This figure shows the formation of a peptide bond, highlighted in blue.
Different amino acids join together to form peptides, polypeptides, or proteins via dehydration synthesis. The bonds between the amino acids are peptide bonds.

The body is able to synthesize most of the amino acids from components of other molecules; however, nine cannot be synthesized and have to be consumed in the diet. These are known as the essential amino acids.

Free amino acids available for protein construction are said to reside in the amino acid pool within cells. Structures within cells use these amino acids when assembling proteins. If a particular essential amino acid is not available in sufficient quantities in the amino acid pool, however, synthesis of proteins containing it can slow or even cease.

Shape of proteins

Just as a fork cannot be used to eat soup and a spoon cannot be used to spear meat, a protein’s shape is essential to its function. A protein’s shape is determined, most fundamentally, by the sequence of amino acids of which it is made ( [link] a ). The sequence is called the primary structure of the protein.

The shape of proteins

This figure shows the secondary structure of peptides. The top panel shows a straight chain, the middle panel shows an alpha-helix and a beta sheet. The bottom panel shows the tertiary structure and fully folded protein.
(a) The primary structure is the sequence of amino acids that make up the polypeptide chain. (b) The secondary structure, which can take the form of an alpha-helix or a beta-pleated sheet, is maintained by hydrogen bonds between amino acids in different regions of the original polypeptide strand. (c) The tertiary structure occurs as a result of further folding and bonding of the secondary structure. (d) The quaternary structure occurs as a result of interactions between two or more tertiary subunits. The example shown here is hemoglobin, a protein in red blood cells which transports oxygen to body tissues.

Questions & Answers

which component of mucus allows it to maintain local level of hydration
Loriann Reply
can the teeth be classify under bones?
Ojaga Reply
Bony prominents
What is the largest muscle in the lower leg
Gwen Reply
what's a nervous system
Dante Reply
Is a the group of neurons and glial cells that work together to receive, integrate and responds appropriately to stimulus in the periphery, spinal cord and brain.
study about internal structure, outer structure and their functions
Navdeep Reply
circulatory system on blood pressure
Lakhu Reply
What is ELISA
(enzyme linked immunosorbent assay) is a test that uses antibodies and color change to identify a substance.
what's defense mechanism?
psychological strategies that are unconsciously used to protect a person from anxiety arising from unacceptable thoughts or feelings.
difference between apocrine sweat glands and merocrine sweat glands
Binkheir Reply
I believe the apocrine sweat gland uses a sac under the hair follicle and the merocrine sweat gland releases directly on to the surface of the skin
normal blood volume in our body
pankaj Reply
Normal blood volume in adults is 6 litres
4.7 to 5ltr.. normal for adult
what are the advantages of the concave shape of red blood cells?
Amy Reply
This structure is VERY flexible. It can allow these cells to get into the most tiny places in our bodies. a VERY good design! The advantage of red blood cells' biconcave shape is that the surface area is increased to allow more haemoglobin to be stored in the cell.
They can stack so that they can move to capillaries
action of gluteus medius and minimus
Green Reply
Lateral rotation of the hip joint
Briefly explain location of ecg on a patient
Prince Reply
it is a machine that gives a graphical representation of heart beat
Briefly explain location of ecg leads on a patient?
in ecg we use electrical leads over the chest ,ancle and wrist
what is the anatomical and function difference between paravertebral and prevertebral ganglia ?
Rada Reply
types of tissue in human
Preety Reply
charactetistic Of cartilaginous tissue
what is theRecurrent infection?
pankaj Reply
what do you mean about recurrent infection
Recurrent or persistent infection is a manifestation of primary immuno deficiency
weakens the immune system, allowing infections and other health problems to occur more easily
lysis of RBC

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