Describe the location and structure of the pancreas, and the morphology and function of the pancreatic islets
Compare and contrast the functions of insulin and glucagon
The
pancreas is a long, slender organ, most of which is located posterior to the bottom half of the stomach (
[link] ). Although it is primarily an exocrine gland, secreting a variety of digestive enzymes, the pancreas has an endocrine function. Its
pancreatic islets —clusters of cells formerly known as the islets of Langerhans—secrete the hormones glucagon, insulin, somatostatin, and pancreatic polypeptide (PP).
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Cells and secretions of the pancreatic islets
The pancreatic islets each contain four varieties of cells:
The
alpha cell produces the hormone glucagon and makes up approximately 20 percent of each islet. Glucagon plays an important role in blood glucose regulation; low blood glucose levels stimulate its release.
The
beta cell produces the hormone insulin and makes up approximately 75 percent of each islet. Elevated blood glucose levels stimulate the release of insulin.
The
delta cell accounts for four percent of the islet cells and secretes the peptide hormone somatostatin. Recall that somatostatin is also released by the hypothalamus (as GHIH), and the stomach and intestines also secrete it. An inhibiting hormone, pancreatic somatostatin inhibits the release of both glucagon and insulin.
The
PP cell accounts for about one percent of islet cells and secretes the pancreatic polypeptide hormone. It is thought to play a role in appetite, as well as in the regulation of pancreatic exocrine and endocrine secretions. Pancreatic polypeptide released following a meal may reduce further food consumption; however, it is also released in response to fasting.
Regulation of blood glucose levels by insulin and glucagon
Glucose is required for cellular respiration and is the preferred fuel for all body cells. The body derives glucose from the breakdown of the carbohydrate-containing foods and drinks we consume. Glucose not immediately taken up by cells for fuel can be stored by the liver and muscles as glycogen, or converted to triglycerides and stored in the adipose tissue. Hormones regulate both the storage and the utilization of glucose as required. Receptors located in the pancreas sense blood glucose levels, and subsequently the pancreatic cells secrete glucagon or insulin to maintain normal levels.
Step 1: Find the mean. To find the mean, add up all the scores, then divide them by the number of scores. ...
Step 2: Find each score's deviation from the mean. ...
Step 3: Square each deviation from the mean. ...
Step 4: Find the sum of squares. ...
Step 5: Divide the sum of squares by n – 1 or N.
The sample of 16 students is taken. The average age in the sample was 22 years with astandard deviation of 6 years. Construct a 95% confidence interval for the age of the population.
Bhartdarshan' is an internet-based travel agency wherein customer can see videos of the cities they plant to visit. The number of hits daily is a normally distributed random variable with a mean of 10,000 and a standard deviation of 2,400
a. what is the probability of getting more than 12,000 hits?
b. what is the probability of getting fewer than 9,000 hits?
Bhartdarshan'is an internet-based travel agency wherein customer can see videos of the cities they plan to visit. The number of hits daily is a normally distributed random variable with a mean of 10,000 and a standard deviation of 2,400.
a. What is the probability of getting more than 12,000 hits
